Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (tumor)

ABSTRACT: Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (tumor)

PROVIDER: PRJNA1001503 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25498605_1.fastq.gz	Fastqsanger.gz
	SRR25498605_2.fastq.gz	Fastqsanger.gz
	SRR25498606_1.fastq.gz	Fastqsanger.gz
	SRR25498606_2.fastq.gz	Fastqsanger.gz
	SRR25498607_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (TCR)

Project description:Immune escape is a prerequisite of tumor growth. We previously described a decline in intratumor activated GZMB+CD8+ T cells and T cell receptor (TCR) clonotype diversity in invasive compared to in situ (DCIS) breast carcinomas implying a role for decreasing TCR diversity in tumor progression. Here, we evaluated peripheral blood TCR clonotype diversity in breast cancer patients diagnosed with DCIS or de novo stage IV disease at different ages. We found that peripheral TCR diversity is associated with clinicopathologic, and peripheral immune status and it correlates with the frequency of CD8+ T cells in DCIS of young patients. These results provide new insights to the role of host immunity and breast cancer development in different aged women.

2024-03-13 | GSE261515 | GEO

Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (TCR)

Project description:Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (TCR)

| PRJNA1087365 | ENA

Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (tumor)

2023-11-09 | GSE239934 | GEO

Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (blood)

2023-11-09 | GSE239933 | GEO

Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression

Project description:Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression

| PRJNA1001408 | ENA

Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (blood)

Project description:Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (blood)

| PRJNA1001501 | ENA

Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-11-09 | GSE239935 | GEO

Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma [TCR-Seq]

Project description:Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma [TCR-Seq]

| PRJNA981115 | ENA

Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity [Exp 1]

Project description:MAIT cells are innate-like T cells that recognize microbial metabolites through a semi-invariant T cell receptor (TCR). Major questions remain regarding the extent of human MAIT cell functional and clonal diversity. To address these, we analyzed the single-cell transcriptome and TCR repertoire of blood and liver MAIT cells and developed functional RNA-sequencing (fRNA-seq), a method to integrate function and TCR clonotype at single-cell resolution. MAIT cell clonal diversity was comparable to conventional memory T cells, with private TCR repertoires shared across matched tissues. Baseline functional diversity was low and largely related to tissue site. MAIT cells showed stimulus-specific transcriptional responses in vitro, with cells positioned along gradients of activation. Clonal identity influenced resting and activated transcriptional profiles, but intriguingly was not associated with the capacity to produce IL-17. Overall, MAIT cells show phenotypic and functional diversity according to tissue localization, stimulation environment, and clonotype.

2023-08-14 | GSE194187 | GEO

Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity [ATAC-seq]

Project description:Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial metabolites through a semi-invariant T cell receptor (TCR). Major questions remain regarding the extent of human MAIT cell functional and clonal diversity. To address these, we analyzed the single-cell transcriptome and TCR repertoire of blood and liver MAIT cells and developed functional RNA sequencing, a method to integrate function and TCR clonotype at single-cell resolution. MAIT cell clonal diversity was comparable to conventional memory T cells, with private TCR repertoires shared across matched tissues. Baseline functional diversity was low and largely related to tissue site. MAIT cells showed stimulus-specific transcriptional responses in vitro, with cells positioned along gradients of activation. Clonal identity influenced resting and activated transcriptional profiles but intriguingly was not associated with the capacity to produce IL- 17. Overall, MAIT cells show phenotypic and functional diversity according to tissue localization, stimulation environment and clonotype.

2023-08-14 | GSE238139 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data