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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation I

ABSTRACT: Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation I

PROVIDER: PRJNA1007678 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25715233_1.fastq.gz	Fastqsanger.gz
	SRR25715233_2.fastq.gz	Fastqsanger.gz
	SRR25715234_1.fastq.gz	Fastqsanger.gz
	SRR25715234_2.fastq.gz	Fastqsanger.gz
	SRR25715235_1.fastq.gz	Fastqsanger.gz

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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation

Project description:Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation

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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation II

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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation III

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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation II

Project description:How biomolecules condense to organize subcellular processes is of fundamental significance. Nitrogen-starved Escherichia coli form a single condensate, which we termed Bacterial Stress Body (BSB). Its formation is triggered by long polyphosphate chains, which scaffold the RNA chaperone Hfq into high molecular weight complexes with distinct sequence-specific RNA and DNA binding properties. We show that polyP is crucial for the stabilization of select RNAs, the sequestration of translation- and RNA metabolism-associated proteins that likely stall protein synthesis, and the specific nucleoid-associated localization of BSBs. Together, these functions ensure bacterial survival and recovery from N-starvation. Mammalian polyphosphate associates with P-bodies but not stress granules suggesting that polyphosphate’s interaction with select RNA binding proteins contributed to the evolution of functionally and compositionally distinct condensates in higher organisms.

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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation I

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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation III

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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation

Project description:This SuperSeries is composed of the SubSeries listed below.

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Local Translation in Nuclear Condensate Amyloid-bodies

Project description:We report that solid-like condensates Amyloid-bodies are hubs of stress-resistant local nuclear translation in cells responding to high temperature. RNA-seq. analysis of purified Amyloid-bodies confirms that HSF1-transcribed mRNAs accumulate in these solid-like condensates during stress.

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Project description:Membraneless nuclear condensates are an emerging model of transcriptional regulation that involves spatially clustered enhancers and genes forming transcription condensates (TCs). We used a physical isolation approach and DNA/nascent RNA analysis to investigate the global organization of the genome in TCs. Comparative analysis of the two revealed the dynamic nature of the genome, with stable localization of promoters, dynamic recruitment of enhancers, and dynamic export of gene bodies out of TCs upon gene activation. Our findings also suggest that the RNA binding protein FUS undergoes decondensation upon nascent RNA binding, facilitating gene body export out of TCs.

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