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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation

ABSTRACT: Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation

PROVIDER: PRJNA1007683 | ENA |

REPOSITORIES: ENA

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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation III

Project description:Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation III

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Bacterial Stress Bodies – Ancestral Condensates Regulating RNA Turnover and Protein Translation III

Project description:How biomolecules condense to organize subcellular processes is of fundamental significance. Nitrogen-starved Escherichia coli form a single condensate, which we termed Bacterial Stress Body (BSB). Its formation is triggered by long polyphosphate chains, which scaffold the RNA chaperone Hfq into high molecular weight complexes with distinct sequence-specific RNA and DNA binding properties. We show that polyP is crucial for the stabilization of select RNAs, the sequestration of translation- and RNA metabolism-associated proteins that likely stall protein synthesis, and the specific nucleoid-associated localization of BSBs. Together, these functions ensure bacterial survival and recovery from N-starvation. Mammalian polyphosphate associates with P-bodies but not stress granules suggesting that polyphosphate’s interaction with select RNA binding proteins contributed to the evolution of functionally and compositionally distinct condensates in higher organisms.

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Project description:This SuperSeries is composed of the SubSeries listed below.

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