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Marah fabacea

ABSTRACT: Marah fabacea Transcriptome or Gene expression

PROVIDER: PRJNA1013276 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29348269_1.fastq.gz	Fastqsanger.gz
	SRR29348269_2.fastq.gz	Fastqsanger.gz
	SRR29348270_1.fastq.gz	Fastqsanger.gz
	SRR29348270_2.fastq.gz	Fastqsanger.gz
	SRR29348271_1.fastq.gz	Fastqsanger.gz

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Project description:Background and purposeThe melastatin-related transient receptor potential TRPM3 is a calcium-permeable nonselective cation channel that can be activated by the neurosteroid pregnenolone sulphate (PregS) and heat. TRPM3-deficient mice show an impaired perception of noxious heat. Hence, drugs inhibiting TRPM3 possibly get in focus of analgesic therapy.Experimental approachFluorometric methods were used to identify novel TRPM3-blocking compounds and to characterize their potency and selectivity to block TRPM3 but not other sensory TRP channels. Biophysical properties of the block were assessed using electrophysiological methods. Single cell calcium measurements confirmed the block of endogenously expressed TRPM3 channels in rat and mouse dorsal root ganglion (DRG) neurones.Key resultsBy screening a compound library, we identified three natural compounds as potent blockers of TRPM3. Naringenin and hesperetin belong to the citrus fruit flavanones, and ononetin is a deoxybenzoin. Eriodictyol, a metabolite of naringenin and hesperetin, was still biologically active as a TRPM3 blocker. The compounds exhibited a marked specificity for recombinant TRPM3 and blocked PregS-induced [Ca(2+)]i signals in freshly isolated DRG neurones.Conclusion and implicationsThe data indicate that citrus fruit flavonoids are potent and selective blockers of TRPM3. Their potencies ranged from upper nanomolar to lower micromolar concentrations. Since physiological functions of TRPM3 channels are still poorly defined, the development and validation of potent and selective blockers is expected to contribute to clarifying the role of TRPM3 in vivo. Considering the involvement of TRPM3 in nociception, TRPM3 blockers may represent a novel concept for analgesic treatment.

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