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Maternal H3.3-Mediated Reprogramming of Parental Genomes during Minor Zygotic Genome Activation [CUT&TAG]

ABSTRACT: Maternal H3.3-Mediated Reprogramming of Parental Genomes during Minor Zygotic Genome Activation [CUT&TAG]

PROVIDER: PRJNA1015619 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26040323_1.fastq.gz	Fastqsanger.gz
	SRR26040323_2.fastq.gz	Fastqsanger.gz
	SRR26040324_1.fastq.gz	Fastqsanger.gz
	SRR26040324_2.fastq.gz	Fastqsanger.gz
	SRR26040325_1.fastq.gz	Fastqsanger.gz

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Maternal H3.3-Mediated Reprogramming of Parental Genomes during Minor Zygotic Genome Activation [CUT&TAG]

Project description:Zygotic gene activation (ZGA) is the first transcription event in life, and is associated with extensive epigenetic reprogramming, which is involved with dynamic incorporation of histone variant H3.3. H3.3 plays essential roles during mouse pre-implantation development. However, the coexistence of distinct sources of H3.3 in early embryos, including paternal and maternal allele-expressed H3.3 (paH3.3 and maH3.3), complicates our ability to track their individual dynamics, which may have distinct roles in embryonic development. In this study, by taking advantage of our H3.3B-HA-tagged mouse model, we illustrated the paH3.3 and maH3.3 landscapes in mouse early embryos, and described the manner of maternal mRNAs-derived H3.3 (mH3.3) on paternal genome reprogramming. We found the deposition of mH3.3 is required for cleavage development and minor ZGA, mechanistically, by mH3.3S31p-meditated acetylation at lysine 27. And, we propose that the mH3.3K27ac modification displaces the repressive histone modifications, thus enabling the activation of minor ZGA genes. Taken together, we demonstrate the central role of mH3.3 in reprogramming parental genomes by establishment of H3K27ac.

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Project description:Maternal H3.3-Mediated Reprogramming of Parental Genomes during Minor Zygotic Genome Activation

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Widespread enhancer dememorization and promoter priming during parental-to-zygotic transition

Project description:The epigenome plays critical roles in controlling gene expression and development. However, how the parental epigenomes transit to the zygotic epigenome in early development remains elusive. Here, we show parental-to-zygotic transition in zebrafish involves extensive erasure of parental epigenetic memory starting by methylating gametic enhancers. Surprisingly, this occurs even prior to fertilization for sperm. Both parental enhancers lose histone marks by the 4-cell stage, and zygotic enhancers are not activated until around zygotic genome activation (ZGA). By contrast, many promoters remain hypomethylated and, unexpectedly, acquire de novo histone acetylation as early as at the 4-cell stage. They then resolve into either activated or repressed promoters upon ZGA. Maternal depletion of histone acetyltransferases results in aberrant ZGA and early embryonic lethality. Finally, such reprogramming is largely driven by maternal factors with zygotic products contributing to embryonic enhancer activation. Thus, these data revealed widespread enhancer dememorization and promoter priming during parental-to-zygotic transition.

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