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A genetically defined mPFC-thalamic circuit underlies pain chronicity

ABSTRACT: A genetically defined mPFC-thalamic circuit underlies pain chronicity

PROVIDER: PRJNA1016417 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26056480_1.fastq.gz	Fastqsanger.gz
	SRR26056480_2.fastq.gz	Fastqsanger.gz
	SRR26056481_1.fastq.gz	Fastqsanger.gz
	SRR26056481_2.fastq.gz	Fastqsanger.gz
	SRR26056482_1.fastq.gz	Fastqsanger.gz

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A genetically defined mPFC-thalamic circuit underlies pain chronicity

Project description:Chronic pain is a major health care problem with great social and economic consequences. Although the medial prefrontal cortex (mPFC) and the thalamus have been implicated in regulating pain, whether and how these regions may involve in pain chronification process have remained largely unknown. Here, we show that Foxp2+ neurons in mPFC, which are corticothalamic (CT) neurons representing the major mPFC output to thalamus, are deactivated in chronic inflammatory pain. Interestingly, prolonged, but not short-term, inactivation of the Foxp2+ neurons in mPFC increases the sensitivity to noxious stimulations. Conversely, chemogenetic activation of this neuronal cluster induces robust antinociceptive effects in both naïve mice and mice with chronic inflammatory pain. Furthermore, we found that the mPFC Foxp2+ neurons project to several thalamic relay nuclei and that activation of the mPFC to the parataenial nucleus of thalamus (PTN) circuit relieves pain. Finally, RNA-seq of the mPFC Foxp2+ neurons revealed that many genes related to neuronal activity are dysregulated in mice with chronic inflammatory pain. Collectively, our studies revealed that Foxp2+ neurons in mPFC that project to thalamus play a critical role in somatosensory processing and pain chronification.

2023-09-16 | GSE243136 | GEO

Chronic Stress Reinforces the BLA-mPFC-LHb Neural Circuit Leading to Depression

Project description:Chronic Stress Reinforces the BLA-mPFC-LHb Neural Circuit Leading to Depression

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Gene expression data from thalamic regions of MPTP-intoxicated mouse brain by acupuncture

Project description:Acupuncture stimulations at GB34 and LR3 inhibit the reduction of tyrosine hydroxylase in the nigrostriatal dopaminergic neurons in the parkinsonism animal models. Especially, behavioral tests showed that acupuncture stimulations improved the motor dysfunction in a previous study. The thalamus is a crucial area for the motor circuit and has been identified as one of the most markedly damaged areas in Parkinson’s disease (PD), so acupuncture stimulations might also have an effect on the thalamic damage. We investigated gene expression profile changes in the thalamic region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism models after acupuncture at the acupoints GB34 and LR3 C57BL/6 mice were divided into four experimental groups; ① C: Control, ② M: MPTP-treatment only, ③ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, ④ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from two brains' thalamic regions of each experimental group (4 experimental group × 2 samples of each experimental group = total 8 samples).

2012-01-18 | E-GEOD-35138 | biostudies-arrayexpress

Persistence of homeostatic sleep drive is encoded by plasticity of a thalamic reuniens circuit

Project description:Persistence of homeostatic sleep drive is encoded by plasticity of a thalamic reuniens circuit

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Chronic Stress Reinforces the BLA-mPFC-LHb Neural Circuit Leading to Depression

Project description:To explore the specific subset of mPFC neurons involved in the pathophysiological process of CRS-induced depression, we performed RNAseq between noCRS and CRS treatment mice to identify the enriched genes and possible pathway. GO:BP analysis identified significantly enriched genes that are involved in synaptic signaling and regulation of membrane potential pathways.

2024-08-17 | GSE274487 | GEO

Gene expression data from thalamic regions of MPTP-intoxicated mouse brain by acupuncture

2012-01-18 | GSE35138 | GEO

Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

Project description:Single-cell RNA-seq was performed in SHH-treated thalamic organoids

2023-04-24 | GSE210720 | GEO

Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

Project description:Single-cell RNA-seq was performed in SHH-treated thalamic organoids

2023-03-31 | GSE226333 | GEO

Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

Project description:Generation of ventralized thalamic organoids with inhibitory thalamic reticular nucleus

| PRJNA867308 | ENA