Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA101705 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:ATAC-seq analysis of medullary thymic epithelial cells deficient in Ascl1
| PRJDB7976 | ENA
Project description:Revisiting the roadmap of medullary thymic epithelial cell differentiation
| PRJNA335745 | ENA
Project description:Gene expression profiling of perinatal or adult medullary thymic epithelial cells (MECs)
| PRJNA276790 | ENA
Project description:Expression data of HDAC3-deficient and sufficient medullary thymic epithelial cells (mTECs)
| PRJNA313087 | ENA
Project description:Expression data from WT and Aire KO thymic medullary epithelial cells (MECs)
| PRJNA148347 | ENA
Project description:Expression data of Sirt1-deficient and sufficient medullary thymic epithelial cells (mTECs)
| PRJNA282514 | ENA
Project description:Thymic medullary epithelial cell (mTEC) expression of the autoimmune regulator AIRE, and of tissue-specific antigens, is controlled by members of the non-canonical NF-kB signalling pathway, including RelB and NF-kB2. Of the genes in this pathway, RelB-/- mice develop a particularly severe multi-organ autoimmune syndrome, resembling Foxp3-deficiency. RelB-/- mice have medullary atrophy and few mTECs but the mechanism is unknown. We show that RelB is required for expression of medullary chemokines and mTEC AIRE, selection of a diverse peripheral T cell repertoire, and for peripheral Foxp3+ Treg function. Vβ families of T cells infiltrating diseased peripheral organs and thymic Treg were similarly skewed. Surprisingly, medullary atrophy results from intra-thymic granulocyte infiltration, consequent upon the Th2-mediated autoimmune disease. Dominant tolerance corrects thymic inflammatory disease and loss of thymic function. We demonstrate a reversible RelB-dependent inflammatory mechanism for loss of central tolerance associated with medullary atrophy. Thymi from 4 RelB+/- mice and 3 RelB-/- mice were profiled by microarays
2012-12-27 | E-GEOD-43154 | biostudies-arrayexpress
Project description:Comparison of ectopic gene expression in Cdx1+/+ and Cdx1-/- thymic medullary epithelial cells
| PRJNA283960 | ENA
Project description:Identification of novel subsets of medullary thymic epithelial cells
| PRJDB5700 | ENA
Project description:Sex hormones have pervasive effects on thymic epithelial cells
| PRJNA278151 | ENA