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Transcript profiling of global PKM2 knockout mouse hearts to evaluate the cardiac role of PKM2 after myocardial infarction

ABSTRACT: Transcript profiling of global PKM2 knockout mouse hearts to evaluate the cardiac role of PKM2 after myocardial infarction

PROVIDER: PRJNA1019361 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26129042_1.fastq.gz	Fastqsanger.gz
	SRR26129042_2.fastq.gz	Fastqsanger.gz
	SRR26129043_1.fastq.gz	Fastqsanger.gz
	SRR26129043_2.fastq.gz	Fastqsanger.gz
	SRR26129044_1.fastq.gz	Fastqsanger.gz

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Transcript profiling of global PKM2 knockout mouse hearts to evaluate the cardiac role of PKM2 after myocardial infarction

Project description:During myocardial infarction (MI), energy production decreases as hypoxia inhibits oxidative metabolism. Our lab has identified an ischemia-regulated alternative splicing event of the glycolytic enzyme pyruvate kinase (muscle, PKM), reducing PKM1 expression and increasing PKM2 expression. We hypothesized the upregulation of PKM2 aids in energy production to maintain heart function after MI. We utilized high-throughput sequencing to evaluate altered gene expression and identify pathways that may be regulated by PKM2.

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