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The function of 3-Indolepropionic acid(IPA) in intestinal homeostasis

ABSTRACT: The function of 3-Indolepropionic acid(IPA) in intestinal homeostasis

PROVIDER: PRJNA1019698 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26142743_1.fastq.gz	Fastqsanger.gz
	SRR26142743_2.fastq.gz	Fastqsanger.gz
	SRR26142744_1.fastq.gz	Fastqsanger.gz
	SRR26142744_2.fastq.gz	Fastqsanger.gz
	SRR26142745_1.fastq.gz	Fastqsanger.gz

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The function of 3-Indolepropionic acid(IPA) in intestinal homeostasis

Project description:Intraepithelial immune cells and intestinal epithelial cells from the small intestine of mice were analyzed for the investigation of the impact of IPA.

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Project description:The incidence and prevalence of inflammatory bowel disease (IBD) is gradually increasing. A high-fat diet (HFD) is known to disrupt intestinal homeostasis and aggravate IBD, yet the underlying mechanisms remain largely undefined. Here, a positive correlation between dietary fat intake and disease severity in both IBD patients and HFD-fed mice is observed. HFD induces a significant decrease in indole-3-acetic acid (IAA) and lead to intestinal barrier damage. Furthermore, IAA supplementation enhances the intestinal mucin sulfation and effectively alleviates colitis. Mechanistically, IAA upregulates key molecules involved in mucin sulfation, including Papss2 and Slc35b3, the synthesis enzyme and the transferase of 3'-phosphoadenosine-5'-phosphosulfate (PAPS), via the Aryl Hydrocarbon Receptor (AHR). More importantly, AHR can directly bind to the transcription start site of Papss2. Oral administration of Lactobacillus reuteri, which can produce IAA, contributes to protecting against colitis and promoting mucin sulfation, while the modified L. reuteri strain lacking the iaaM gene (LactobacillusΔiaaM) and the ability to produce IAA fails to exhibit such effects. Overall, IAA enhances intestinal mucin sulfation through AHR, contributing to the protection of intestinal homeostasis.

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