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Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells 4+4

ABSTRACT: Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells 4+4

PROVIDER: PRJNA1020182 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26152252_1.fastq.gz	Fastqsanger.gz
	SRR26152252_2.fastq.gz	Fastqsanger.gz
	SRR26152253_1.fastq.gz	Fastqsanger.gz
	SRR26152253_2.fastq.gz	Fastqsanger.gz
	SRR26152254_1.fastq.gz	Fastqsanger.gz

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Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells

Project description:Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells

| PRJNA1020181 | ENA

Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells 4+4

Project description:We isolated CD4+ T cells from mice vaccinated against, and challenged with, Brucella to investigate the function of CD4+ T cell intrinsic BCL6 signaling

2024-01-24 | GSE243861 | GEO

Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells 4+2

Project description:We isolated CD4+ T cells from mice vaccinated against, and challenged with, Brucella to investigate the function of CD4+ T cell intrinsic BCL6 signaling

2024-01-24 | GSE243859 | GEO

Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells 4+2

Project description:Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells 4+2

| PRJNA1020178 | ENA

Bcl6 controlled gene expression in naïve CD4 T cells (Tf0)

Project description:Gene expression data from wild-type and Bcl6-/- naive CD4 T cells In order to find genes regulated by Bcl6 in follicular helper T cells Naïve CD4 T cells were sorted from wild-type (WT) and T cell-specific conditional Bcl6-/- (KO) mice-- 8 samples, 4 WT and 4 KO

2015-04-08 | E-GEOD-67622 | biostudies-arrayexpress

Bcl6 controlled gene expression in naïve CD4 T cells (Tfh)

2015-04-08 | E-GEOD-67623 | biostudies-arrayexpress

Expression data from BCL6-YFP-positive Tfh cells, BCL6-YFP-negative Tfh cells, non-Tfh cells, and naïve helper T cells.

Project description:We found that a number of Tfh cells downmodulated BCL6 protein after their development, and we sought to compare the gene expression between BCL6-hi Tfh cells and BCL6-low Tfh cells. CD4+ T cells were sorted from immunized and non-immunized mice for RNA extraction and hybridization on Affymetrix microarrays. Bcl6yfp/+ OT-II cells were transferred to congenic recipient mice, and immunized with NP-OVA in CFA subcutaneously. Seven or ten days after immunization, cells were collected from draining lymph nodes, and sorted on FACSAria by the expression of CXCR5, PD-1 and BCL6-YFP. Naive CD4+ T cells were CD4+ CD44lo CD62Lhi cells from unimmunized mice.

2011-06-02 | E-GEOD-24574 | biostudies-arrayexpress

Bcl6 controlled gene expression in naïve CD4 T cells (Tfh)

Project description:Gene expression data from wild-type and Bcl6-/- naive CD4 T cells In order to find genes regulated by Bcl6 in follicular helper T cells

2015-04-08 | GSE67623 | GEO

Bcl6 controlled gene expression in naïve CD4 T cells (Tf0)

Project description:Gene expression data from wild-type and Bcl6-/- naive CD4 T cells In order to find genes regulated by Bcl6 in follicular helper T cells

2015-04-08 | GSE67622 | GEO

Dependence on Bcl6 and Blimp1 identifies distinct mechanisms driving memory and follicular helper CD4+ T cell differentiation [scRNA-Seq]

Project description:During the immune response, CD4+ T cells differentiate into distinct effector subtypes, including follicular helper T (Tfh) cells that help B cells, and into memory cells. Tfh and memory cells are required for long-term immunity; both depend on the transcription factor Bcl6, raising the question of whether they differentiate through similar mechanisms. Here, using notably single-cell RNA and ATAC sequencing, we show that virus-responding CD4+ T cells lacking both Bcl6 and Blimp1 can differentiate into cells with transcriptomic, chromatin accessibility and function attributes of memory cells, but not of Tfh cells. Thus, Bcl6 promotes memory cell differentiation primarily through its repression of Blimp1. These findings demonstrate that distinct mechanisms underpin the differentiation of memory and Tfh CD4+ cell and define the Bcl6-Blimp1 axis as a potential target for promoting long-term memory T cell differentiation.

2021-11-14 | GSE184847 | GEO

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