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Gene expression of injured DRGs from WT and Fmn2-/- mice

ABSTRACT: Gene expression of injured DRGs from WT and Fmn2-/- mice

PROVIDER: PRJNA1020422 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26156287_1.fastq.gz	Fastqsanger.gz
	SRR26156287_2.fastq.gz	Fastqsanger.gz
	SRR26156288_1.fastq.gz	Fastqsanger.gz
	SRR26156288_2.fastq.gz	Fastqsanger.gz
	SRR26156289_1.fastq.gz	Fastqsanger.gz

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Gene expression of injured DRGs from WT and Fmn2-/- mice

Project description:Current study aimed to identify the gene expression change that are unique in injured Fmn2-/- DRGs compared with WT mice.

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Gene expression in mouse DRG neurons at 2 or 5 days post-sciatic lesion in WT and Nfil3-KO

Project description:Mice with a deletion of transcription factor Nfil3 show delayed functional regeneration after sciatic lesion compared to WT mice. To analyze differential gene expression, sciatic nerves were lesioned and nerve endings were coaptated. After two or 5 days, DRGs L4 and L5 were dissected out and gene expression was measured by microarray. Control tissue was taken from the non-injured side. We found that expression of classic regeneration associated genes was similar in WT and Nfil3 KO mice. We did identify a group of differentially expressed genes known for its role in olfactory signal transduction, but were not known as regeneration associated genes until now, which may explain the negative effects on functional recovery. Gene expression in DRGs L4 and L5 from WT and NFIL3 KO mice was analyzed at 2 and 5 days after receiving a sciatic nerve lesion. Control tissue was taken from the non-injured side. Four biological replicates were used per condition. Microarray chips were two color chips, but each channel was analyzed in single color fashion. Conditions were pseudo-randomized over chips in a balanced dye-swap setup.

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Time-dependent gene expression patterns in injured brains of WT and LRRK2 G2019S mice.

Project description:The effects of the LRRK2 G2019S (GS) mutation on brain injury and recovery from injury were examined by comparing time-dependent gene expression patterns in injured brains of WT and GS mice, beginning 6 h after injury to almost complete repair 15 days later. Brain injury was induced by stereotaxic injection of ATP, a component of damage-associated molecular patterns (DAMPs), into the striatum.

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Time-dependent gene expression patterns in injured brains of WT and LRRK2 G2019S mice.

Project description:Time-dependent gene expression patterns in injured brains of WT and LRRK2 G2019S mice.

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Single Cell Atlas of Injured Sciatic Nerve Tissue

Project description:Sciatic nerve crush (SNC) triggers sterile inflammation within the distal nerve and de-afferented dorsal root ganglia (DRGs). In the nerve, neutrophils and pro-inflammatory Ly6Chigh monocytes appear first and rapidly give way to Ly6Clow resolving macrophages. Transcriptional profiling of injured nerve tissue identifies six macrophage subpopulations, repair Schwann cells and mesenchymal cells as the main cell types. Macrophages at the nerve crush site are distinct from macrophages associated with degenerating nerve fibers. Monocytes and macrophages in the injured nerve “eat” apoptotic cell corpses of leukocytes and thereby contribute to an anti-inflammatory milieu. Studies with chimeric mice show that following SNC few blood-derived immune cells enter DRGs. Myeloid cells in the injured nerve, but not DRGs, express the receptor for the chemokine GM-CSF. In the absence of GM-CSF, conditioning-lesion induced regeneration of DRG neuron central projections is abrogated. Thus, a carefully orchestrated immune response in the nerve is required for conditioning-lesion induced neurorepair.

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Gene expression in mouse DRG neurons at 2 or 5 days post-sciatic lesion in WT and Nfil3-KO

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Gene expression in islets from βUCP2Tg mice and WT mice

Project description:Gene expression in islets from βUCP2Tg mice and WT mice

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Expression from L4/5 DRGs after oral administration of LBP

Project description:Current study found that oral administration markedly increased the growth capacity of DRG neurons. In this dataset, we identified genes that were differentially expressed in L4/5 DRGs after oral administration of LBP

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