Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Modeling pre-implantation development using totipotent blastomere-like stem cells [scRNA-seq]

ABSTRACT: Modeling pre-implantation development using totipotent blastomere-like stem cells [scRNA-seq]

PROVIDER: PRJNA1020574 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Modeling pre-implantation development using totipotent blastomere-like stem cells

Project description:Modeling pre-implantation development using totipotent blastomere-like stem cells

| PRJNA1020571 | ENA

Modeling pre-implantation development using totipotent blastomere-like stem cells [ATAC-seq]

Project description:Modeling pre-implantation development using totipotent blastomere-like stem cells [ATAC-seq]

| PRJNA1020575 | ENA

Modeling pre-implantation development using totipotent blastomere-like stem cells [Cut&tag]

Project description:Modeling pre-implantation development using totipotent blastomere-like stem cells [Cut&tag]

| PRJNA1020576 | ENA

Modeling pre-implantation development using totipotent blastomere-like stem cells [bulk RNA-seq]

Project description:Modeling pre-implantation development using totipotent blastomere-like stem cells [bulk RNA-seq]

| PRJNA1020573 | ENA

Modeling pre-implantation development using totipotent blastomere-like stem cells [scRNA-seq]

Project description:we have established TBLC-based differentiation systems to recapitulate the entire pre-implantation development

2025-01-17 | GSE243922 | GEO

Modeling pre-implantation development using totipotent blastomere-like stem cells [ATAC-seq]

Project description:we have established TBLC-based differentiation systems to recapitulate the entire pre-implantation development Assay for transposase accessible chromatin with high-throughput sequencing in mESC sand mTBLCs

2025-01-17 | GSE243924 | GEO

Modeling pre-implantation development using totipotent blastomere-like stem cells [Cut&tag]

Project description:we have established TBLC-based differentiation systems to recapitulate the entire pre-implantation development Cleavage under target & tagmentation (CUT&Tag)-sequencing (CUT&Tag) for H3K4me3,H3K27ac,H3K9me3,RNA polymerase II(Pol2) and h3k27me3 in mPSC sand mTBLCs

2025-01-17 | GSE243923 | GEO

Modeling pre-implantation development using totipotent blastomere-like stem cells [bulk RNA-seq]

Project description:we have established TBLC-based differentiation systems to recapitulate the entire pre-implantation development Poly(A) RNA-seq is performed on mTBLCs cultured in 2MYCP medium

2025-01-17 | GSE243921 | GEO

Remodeling the step-wise mouse placental development by using totipotent blastomere-like stem cells [WGBS]

Project description:During development, totipotent blastomeres initiate the first cell fate decision to generate inner cell mass and trophectoderm. The trophectoderm forms the placenta mediating fetal-maternal communications, while placental deficiencies cause infertility and pregnancy disorders in humans. However, in vitro systems remodeling the step-wise placental development, particularly encompassing the pre-implantation phase, are still unavailable. Here, using mouse totipotent blastomere-like cells (TBLCs), we successfully realize inducing and long-term maintaining trophectoderm-like stem cells (TELSCs), and further generating placental trophoblast organoids. Interestingly, an intermediate morula trophectoderm-like cells (TELCs) were transiently induced from TBLCs, and quickly converted into TELSCs assembling blastocyst trophectoderm. In 3D culturing condition, TELSCs can form rosette-like structures at peri-implantation period, to eventually generate trophoblast organoids, in which trophoblast progenitors/giant cells, spongiotrophoblasts and syncytiotrophoblasts were all identified at the single-cell level. Transcriptomic and epigenomic analyses enable tracing the step-by-step transition from TBLCs to mature trophoblast lineages. Thus, this study provides a comprehensive differentiation system to understand and investigate placental development.

2025-01-01 | GSE251984 | GEO

Remodeling the step-wise mouse placental development by using totipotent blastomere-like stem cells [scRNA-seq]

2025-01-01 | GSE251983 | GEO