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Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM-GFP and RPMA ONB tumors]

ABSTRACT: Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM-GFP and RPMA ONB tumors]

PROVIDER: PRJNA1021258 | ENA |

REPOSITORIES: ENA

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Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM-GFP and RPMA ONB tumors]

Project description:The olfactory epithelium relies on active neuron regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare, aggressive tumor of unclear origins. Here, we establish a new, highly-penetrant, genetically-engineered mouse model of ONB with alterations in Rb1/Trp53/Myc that exhibit a NEUROD1+ immature neuronal state. ASCL1 loss leads to emergence of non-neuronal histopathologies, including a POU2F3+ microvillar-like state. We find ONB tumor heterogeneity to recapitulate developmental states of multipotent globose basal cells (GBCs), which our data demonstrate is a cell of origin for ONB. Similar to small cell lung cancer (SCLC), mouse and human ONB exhibit: mutually exclusive ASCL1, NEUROD1, and POU2F3- like states, an immune-cold tumor microenvironment, intratumoral subtype heterogeneity comprising neuronal and non-neuronal lineages, and subtype plasticity—as evidenced by barcode-based lineage tracing and single-cell transcriptomics. Collectively, our findings highlight conserved developmental trajectories between ONB and SCLC subtypes with significant implications for ONB classification and treatment.

2024-05-15 | GSE244122 | GEO

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer

Project description:Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer

| PRJNA1021254 | ENA

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM and RPMA GBC-derived allograft tumors, CellTagged]

2024-05-15 | GSE244119 | GEO

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM and RPMA GBC-derived allograft tumors, CellTagged]

Project description:Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single cell RNA seq on RPM and RPMA GBC-derived allograft tumors, CellTagged]

| PRJNA1021257 | ENA

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single nucleus RNA-seq on human ONB tumor]

2024-05-15 | GSE248746 | GEO

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Spatial transcriptomics on de-identified human ONB samples]

2024-05-15 | GSE244117 | GEO

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Spatial transcriptomics on de-identified human ONB samples]

Project description:Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Spatial transcriptomics on de-identified human ONB samples]

| PRJNA1021255 | ENA

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single nucleus RNA-seq on human ONB tumor]

Project description:Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer [Single nucleus RNA-seq on human ONB tumor]

| PRJNA1045693 | ENA

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-05-15 | GSE244123 | GEO

Comparison of olfactory sensory neuron subtypes

Project description:Olfactory sensory neurons (OSNs) express a single abundant olfactory receptor (OR). To assess the differences in gene expression between different OSN sub-types we collected three pools of neurons that express one OR and compared them to three pools of neurons that express another. After extracting RNA from these pools, the samples were multiplexed and sequenced using the Illumina Hiseq2500 platform.This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

2016-02-09 | E-ERAD-436 | biostudies-arrayexpress

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