Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Uncovering systemic immunological modification by type 2 diabetes mellitus in periodontitis patients via single-cell RNA analysis

ABSTRACT: Uncovering systemic immunological modification by type 2 diabetes mellitus in periodontitis patients via single-cell RNA analysis

PROVIDER: PRJNA1023400 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26264500_1.fastq.gz	Fastqsanger.gz
	SRR26264500_2.fastq.gz	Fastqsanger.gz
	SRR26264501_1.fastq.gz	Fastqsanger.gz
	SRR26264501_2.fastq.gz	Fastqsanger.gz
	SRR26264502_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 54

Similar Datasets

Uncovering systemic immunological modification by type 2 diabetes mellitus in periodontitis patients via single-cell RNA analysis

Project description:Type 2 diabetes mellitus (DM) is a complex metabolic disorder and leads to various complications including periodontitis (PD). Though bidirectional relationship of DM and PD has been reported, however, their immunological relationship remain poorly understood. This study aims to compare the immune response in patients with PD only and those with both PD and DM (PDDM), in order to expand our knowledge of the complicated connections between PD and DM. We collected peripheral blood mononuclear cells (PBMCs) from three distinct groups: 11 healthy control subjects, 10 patients with PD without DM, and 6 patients with PDDM. PBMCs were analyzed using single-cell RNA sequencing.

2023-12-20 | GSE244515 | GEO

Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes

Project description:Treatment of periodontitis in people with diabetes remains challenging. Diabetes-enhanced oxidative stress is a primary cause of aggravation of periodontitis. The present study aimed to investigate the therapeutic potential of thioredoxin-1 (TRX1), an essential endogenous antioxidant protein, in the management of periodontitis with diabetes, as well as its role in modulating osteogenic differentiation. Our findings indicated that the production of reactive oxygen species (ROS) was elevated, while the expression of TRX1 was significantly reduced in the periodontal tissues of periodontitis mice with diabetes. Furthermore, knockdown of TRX1 in periodontal ligament stem cells (PDLSCs) resulted in the inhibition of osteogenic differentiation through disrupting Wnt/β-catenin signal pathway. However, this inhibition was restored upon administration of recombinant human TRX1 (rhTRX1). Importantly, rhTRX1 treatment decreased ROS generation, activated Wnt/β-catenin signal pathway and considerably promoted the alveolar bone repair of periodontitis mice with diabetes. These findings highlighted the crucial protective role of TRX1 in periodontitis with diabetes and suggested that it may serve as a potential therapeutic target for refractory periodontitis associated with oxidative stress.

2023-09-06 | GSE235930 | GEO

Diabetes Mellitus Type 1 miRnome

Project description:Diabetes Mellitus Type 1 miRnome

| PRJEB51173 | ENA

Type 2 Diabetes mellitus: mRNA and miRNA profiling

Project description:This SuperSeries is composed of the following subset Series: GSE21321: Blood microRNA profiles and upregulation of hsa-miR-144 in males with type 2 diabetes mellitus. GSE26167: MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in Type 2 Diabetes mellitus Refer to individual Series

2010-12-18 | E-GEOD-26168 | biostudies-arrayexpress

Post-transplant diabetes mellitus after kidney transplantation

Project description:Diabetes mellitus (DM) after transplantation remains a crucial clinical problem in kidney transplantation. To obtain insights into molecular mechanisms underlying the development of post-transplant diabetes mellitus (PTDM) and its early impact on glomerular structures, here we comparatively analyze the proteome of histologically normal appearing glomeruli from patients with PTDM from normoglycemic (NG) transplant recipients, and from recipients with pre-existing type 2 DM (PTDM)

2023-10-24 | PXD042188 | Pride

Serum microRNA profile of human type 1 diabetes mellitus

Project description:To evaluate whether serum micoRNAs can be biomarkers for diagnosis of type 1 diabetes mellitus, we analyzed the serum microRNA expression profiles in 6 patients with new-onset type 1 diabetes mellitus and 6 age- and gender-matched healthy controls. A difference was observed in 31 miRNAs between the patients and controls (fold change ≥ 2, P < 0.05)

2017-02-09 | GSE94649 | GEO

RNAseq between gestational diabetes mellitus and healthy control groups

Project description:tsRNA profiles of gestational diabetes mellitus and healthy control groups were generated by deep sequencing using Illumina NextSeq 500.

2024-05-12 | GSE267259 | GEO

DNA methylation and gestational diabetes mellitus

Project description:DNA methylation and gestational diabetes mellitus

| PRJEB66494 | ENA

Transcriptional profile of peripheral blood mononuclear cells from Gestational Diabetes Mellitus Patients

Project description:The oligo microarray were used to determine gene expression profile of PBMC from gestational diabetes mellitus (GDM) patients.

2012-08-25 | E-MEXP-3349 | biostudies-arrayexpress

Apical periodontitis

Project description:Apical periodontitis

| PRJEB11764 | ENA