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Uncovering systemic immunological modification by type 2 diabetes mellitus in periodontitis patients via single-cell RNA analysis

ABSTRACT: Uncovering systemic immunological modification by type 2 diabetes mellitus in periodontitis patients via single-cell RNA analysis

PROVIDER: PRJNA1023400 | ENA |

REPOSITORIES: ENA

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Uncovering systemic immunological modification by type 2 diabetes mellitus in periodontitis patients via single-cell RNA analysis

Project description:Type 2 diabetes mellitus (DM) is a complex metabolic disorder and leads to various complications including periodontitis (PD). Though bidirectional relationship of DM and PD has been reported, however, their immunological relationship remain poorly understood. This study aims to compare the immune response in patients with PD only and those with both PD and DM (PDDM), in order to expand our knowledge of the complicated connections between PD and DM. We collected peripheral blood mononuclear cells (PBMCs) from three distinct groups: 11 healthy control subjects, 10 patients with PD without DM, and 6 patients with PDDM. PBMCs were analyzed using single-cell RNA sequencing.

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Project description:Treatment of periodontitis in people with diabetes remains challenging. Diabetes-enhanced oxidative stress is a primary cause of aggravation of periodontitis. The present study aimed to investigate the therapeutic potential of thioredoxin-1 (TRX1), an essential endogenous antioxidant protein, in the management of periodontitis with diabetes, as well as its role in modulating osteogenic differentiation. Our findings indicated that the production of reactive oxygen species (ROS) was elevated, while the expression of TRX1 was significantly reduced in the periodontal tissues of periodontitis mice with diabetes. Furthermore, knockdown of TRX1 in periodontal ligament stem cells (PDLSCs) resulted in the inhibition of osteogenic differentiation through disrupting Wnt/β-catenin signal pathway. However, this inhibition was restored upon administration of recombinant human TRX1 (rhTRX1). Importantly, rhTRX1 treatment decreased ROS generation, activated Wnt/β-catenin signal pathway and considerably promoted the alveolar bone repair of periodontitis mice with diabetes. These findings highlighted the crucial protective role of TRX1 in periodontitis with diabetes and suggested that it may serve as a potential therapeutic target for refractory periodontitis associated with oxidative stress.

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Project description:This SuperSeries is composed of the following subset Series: GSE21321: Blood microRNA profiles and upregulation of hsa-miR-144 in males with type 2 diabetes mellitus. GSE26167: MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in Type 2 Diabetes mellitus Refer to individual Series

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