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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional profile of peripheral blood mononuclear cells from Gestational Diabetes Mellitus Patients

ABSTRACT: The oligo microarray were used to determine gene expression profile of PBMC from gestational diabetes mellitus (GDM) patients.

ORGANISM(S): Homo sapiens

DISEASE(S): Controled disease patient

SUBMITTER: Geraldo Passos

PROVIDER: E-MEXP-3349 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative analysis of the transcriptome profiles observed in type 1, type 2 and gestational diabetes mellitus reveals the role of inflammation.

Evangelista Adriane F AF Collares Cristhianna V A CV Xavier Danilo J DJ Macedo Claudia C Manoel-Caetano Fernanda S FS Rassi Diane M DM Foss-Freitas Maria C MC Foss Milton C MC Sakamoto-Hojo Elza T ET Nguyen Catherine C Puthier Denis D Passos Geraldo A GA Donadi Eduardo A EA

BMC medical genomics 20140523

<h4>Background</h4>Type 1 diabetes (T1D) is an autoimmune disease, while type 2 (T2D) and gestational diabetes (GDM) are considered metabolic disturbances. In a previous study evaluating the transcript profiling of peripheral mononuclear blood cells obtained from T1D, T2D and GDM patients we showed that the gene profile of T1D patients was closer to GDM than to T2D. To understand the influence of demographical, clinical, laboratory, pathogenetic and treatment features on the diabetes transcript ...[more]

PMID: 24885568

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Project description:The microRNA (miRNA) expression profile of plasma exosome in pregnant women complicated with gestational diabetes mellitus (GDM) has not been fully clarified. In this study, differentially expressed miRNAs in plasma exosomes were identified by high-throughput small RNA sequencing in 12 GDM and 12 normal glucose tolerance (NGT) pregnant women and validated in 102 GDM and 101 NGT pregnant women. A total of 22 exosomal miRNAs were found and five of them were verified by qRT-PCR. Exosomal miR-423-5p was upregulated, while miR-99a-5p, miR-192-5p, miR-148a-3p, and miR-122-5p were downregulated in pregnant women complicated with GDM.

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DIA proteomics for gestational diabetes mellitus

Project description:Gestational diabetes mellitus (GDM), one of the most common pregnancy complications, affects approximately 6% of pregnancies. This study attempted to use the data-independent acquisition (DIA) mass spectrometry (MS) to identify the potential protein biomarkers from the placental tissues from the GDM patients and the normal pregnant women.

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Transcriptional profiles of microRNAs from peripheral blood mononuclear cells of type 1 diabetes mellitus patients

Project description:The microRNA oligo microarrays were used to determine expression profiles of peripheral blood mononuclear cells from type 1 diabetes mellitus (T1DM) patients, aiming the identification of possible disease related MicroRNAs.

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Project description:The hemochorial placenta provides a critical barrier at the maternal-fetal interface to modulate maternal immune tolerance and enable gas and nutrient exchange between mother and conceptus. Pregnancy outcomes are adversely affected by gestational diabetes mellitus (GDM); however, the effects of GDM on placental formation, and subsequently fetal development, are not fully understood. In this report, streptozotocin was used to induce hyperglycemia in pregnant rats for the purpose of investigating the impact of GDM on placental formation and fetal development. GDM caused placentomegaly and placenta malformation, decreasing placental efficiency and fetal size. Elevated glucose disrupted rat trophoblast stem (TS) cell differentiation in vitro. Evidence of altered trophoblast differentiation was also observed in vivo, as hyperglycemia affected the junctional zone transcriptome and interfered with intrauterine trophoblast invasion and uterine spiral artery remodeling. When exposed to hypoxia, rats with GDM showed decreased proliferation and ectoplacental cone development on gestation day (gd) 9.5 and complete pregnancy loss by gd 13.5. Furthermore, elevated glucose concentrations inhibited TS cell responses to hypoxia in vitro. Overall, these results indicate that alterations in placental development, efficiency, and plasticity could contribute to the suboptimal fetal outcomes in offspring from pregnancies complicated by GDM.

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