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Expression data from platelets from early NSCLC and HNSCC patients in tumour presence and tumor free samples

ABSTRACT: Expression data from platelets from early NSCLC and HNSCC patients in tumour presence and tumor free samples

PROVIDER: PRJNA1023957 | ENA |

REPOSITORIES: ENA

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Expression data from platelets from early NSCLC and HNSCC patients in tumour presence and tumor free samples

Project description:Gene expression profile of platelets. In this study, we try to address the knowledge gap regarding liquid biopsy markers for early detection of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC). For that blood samples were collected in two time points, in the presence and absence of NSCLC or HNSCC. Platelets were isolated and gene expression evaluated by microarray technique.

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Project description:Gene expression profile of platelets have been explored due to their stability and abundance in plasma. In this study, we try to address the knowledge gap regarding liquid biopsy markers for early detection of non-small cell lung cancer (NSCLC). For that blood samples were collected in two time points, in the presence and absence of NSCLC. Platelets were isolated and miRNA expression evaluated by microarray technique.

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HNSCC Cells: ctrl vs six tumour lethal miRNAs transfected

Project description:Some microRNAs have antiproliferative effects in cells and are believed to act as tumour suppressors. We used a retroviral human microRNA expression library to identify six microRNAs, miR-181a, miR-323, miR-326, miR-342, miR345 and miR-371, that induce antiproliferative effects in head and neck squamous cell carcinoma (HNSCC), but do not in normal oral keratinocytes. By gene expression profilling we showed that the ataxia telangiectasia mutated (ATM) gene is a common target for three of these microRNAs. Transcriptional profilling of head and neck cancer cells comparing transiently transfected with either one of the six miRNAs to the cells transfected with a control vector. One-condition experiment, ctrl vs miRNA transfected, Biological replicates: 2 replicates for each miRNA transfected, 4 replicates for ctrl transfected

2013-11-06 | E-GEOD-34881 | biostudies-arrayexpress

HNSCC Cells: ctrl vs six tumour lethal miRNAs transfected

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Project description:We report RNA-sequencing data of 779 blood platelet samples, including 402 tumor-educated platelet (TEP) samples collected from patients with non-small cell lung cancer (NSCLC). In addition, we report RNA-sequencing data of blood platelets isolated from 377 individuals without reported cancer, but not excluding individuals with inflammatory conditions. This dataset highlights the ability of TEP RNA-based 'liquid biopsy' diagnostics in patients with NSCLC.

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Transcriptome profiling of human ovarian cancer cell lines grown in the presence and absence of washed human platelets

Project description:The objective of the study was to determine the influence of platelets on the transcriptome profile of ovarian cancer cells Ovarian cancer cell lines (SKOV3 and 59M) were co-cultured with human washed platelets for 24 hours prior to RNA extraction. These samples were then analysed on affymetrix human Gene 2.0ST arrays.

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Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer

Project description:The composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and restricting anti-tumour therapies through multiple mechanisms. The characterisation of differences in ECM composition between normal and diseased tissues may aid in identifying novel diagnostic markers, prognostic indicators and therapeutic targets for drug development. Using tissue from non-small cell lung cancer (NSCLC) patients undergoing curative intent surgery, we characterised quantitative tumour-specific ECM proteome signatures by mass spectrometry, identifying 161 matrisome proteins differentially regulated between tumour tissue and nearby non-malignant lung tissue. We defined a collagen hydroxylation functional protein network that is enriched in the lung tumour microenvironment. We validated two novel putative extracellular markers of NSCLC, the collagen cross-linking enzyme peroxidasin and a disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAMTS16), for discrimination of malignant and non-malignant lung tissue. These proteins were up-regulated in lung tumour samples, and high PXDN and ADAMTS16 gene expression was associated with shorter survival of lung adenocarcinoma and squamous cell carcinoma patients, respectively. These data reveal tumour matrisome signatures in human NSCLC.

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