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Spatial transcriptomics of mouse spleens during steady state and malaria infection. [d0_d7_slideseqV2]

ABSTRACT: Spatial transcriptomics of mouse spleens during steady state and malaria infection. [d0_d7_slideseqV2]

PROVIDER: PRJNA1024927 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26302310.fastq.gz	Fastqsanger.gz
	SRR26302311.fastq.gz	Fastqsanger.gz
	SRR26302312.fastq.gz	Fastqsanger.gz
	SRR26302313.fastq.gz	Fastqsanger.gz
	SRR26302314.fastq.gz	Fastqsanger.gz

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Spatial transcriptomics of mouse spleens during steady state and malaria infection. [d0_d7_slideseqV2]

Project description:Blood-stage malaria infection induces differentiation of several effector CD4 + T subsets including Tfh and Th1 cells. The cues and microarchitectural niches required in secondary lymphoid organs for their formation were previously uncharacterised. Here we used spatial transcriptomics to characterise the microarchitecture of mouse spleen before and during malaria infection, and mapping the spatial and molecular requirements of Tfh/Th1 differentiation.

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