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Transcriptome analysis of the mouse fetal and adult rete ovarii and surrounding tissues

ABSTRACT: Transcriptome analysis of the mouse fetal and adult rete ovarii and surrounding tissues

PROVIDER: PRJNA1025006 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26313449_1.fastq.gz	Fastqsanger.gz
	SRR26313449_2.fastq.gz	Fastqsanger.gz
	SRR26313450_1.fastq.gz	Fastqsanger.gz
	SRR26313450_2.fastq.gz	Fastqsanger.gz
	SRR26313452_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of the mouse fetal and adult rete ovarii and surrounding tissues

Project description:The rete ovarii (RO) is an epithelial structure that arises during fetal development in close proximity to the ovary, and persists throughout adulthood in mammals. However, the functional significance of the RO remains elusive and it has been absent from recent discussions of female reproductive anatomy. The RO comprises three distinct regions: the intraovarian rete (IOR) within the ovary, the extraovarian rete (EOR) in the periovarian tissue, and the connecting rete (CR) linking the EOR and IOR. We hypothesize that the RO plays a pivotal role in maintaining ovarian homeostasis and responding to physiological changes. To uncover the nature and function of RO cells, we conducted transcriptome analysis, encompassing bulk, single-cell, and nucleus-level sequencing of both fetal and adult RO tissues using the Pax8-rtTA; Tre-H2B-GFP mouse line, where all RO regions express nuclear GFP. This study presents three datasets, which highlight RO-specific gene expression signatures and reveal differences in gene expression across the three RO regions during development and in adulthood. The integration and rigorous validation of these datasets will advance our understanding of the RO's roles in ovarian development, female maturation, and adult female fertility.

2023-11-07 | GSE244849 | GEO

Transcriptional comparison of Testicular Adrenal Rest Tumors with fetal and adult tissues

Project description:By comparing the transcriptome of TART with fetal- and adult- testis and adrenal tissues, this study aimed to unravel the origin of TART. Sixteen TART samples were previously obtained from patients with CAH (n=7) or recurrent Cushing’s Disease (n=1). Adult adrenal (n=11), adult testis (n=10), fetal adrenal (n=13), and fetal testis (n=5) tissues were obtained.

2023-06-12 | GSE196700 | GEO

Expression data from mouse fetal and adult intestinal organoid cultures and intestinal tissues

Project description:Here we profiled fetal intestinal epithlelium derived organoids at day 3 (group1) and 30 (group2) of culture, adult orgnanoids at day 3 (group3) and 30 (group4) of culture and whole intestinal tissues at P0(group5) and adult (group6).

2018-12-01 | GSE118982 | GEO

Quantitative Proteomic Analysis of Mouse Fetal and Adult Hematopoietic Progenitor Cells

Project description:Quantitative proteomic analysis of mouse fetal and adult hematopoietic progenitor cells using TMT6plex and an SPS-MS3 method.

2020-07-02 | MSV000085672 | MassIVE

Expression data from mouse fetal and adult intestinal organoid cultures and intestinal tissues

Project description:Expression data from mouse fetal and adult intestinal organoid cultures and intestinal tissues

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Long-Term Persistence of Fetal Hepatocyte Gene Expression and Histone Modification Signatures Following Transplantation to Adult Liver

Project description:Introduction: Hepatic cell transplantation offers an alternative to orthotopic liver transplantation for chronic liver disease. We previously demonstrated that fetal rat hepatocytes durably persist and proliferate when transplanted to an injured adult liver. To identify mechanisms underlying fetal hepatocyte repopulation, we profiled gene expression and histone post-translational modifications (hPTM) of post-transplantation fetal colonies and surrounding liver, as well as those of primary fetal and adult hepatocytes. Methods: Using the DPPIV rat model, we transplanted and traced fetal hepatocytes into adult hosts. At 10 months after transplantation, we used laser capture microscopy to isolate fetal-derived colonies and surrounding adult host tissue. RNA and histones were extracted from laser captured tissue and isolated hepatocytes for RNA-seq and quantitation of hPTM. Results: Principal component analysis of RNA-seq results discriminated between fetal-derived colonies and surrounding adult host tissue. We identified 953 differentially expressed genes, many of which were significantly overexpressed in pre-transplant fetal hepatocytes relative to adult hepatocytes. This gene set included a disproportionate number of genes encoding ion transmembrane transporters. Proteomic analyses identified 13 distinct marks on Histone H3 whose relative abundance differed significantly between fetal-derived colonies and adult host tissue. Of these 13 marks, 11 had abundance profiles similar to those of fetal hepatocytes. Conclusions: A distinct gene expression and epigenetic profile seen in pre-transplant fetal cells is retained for at least 10 months following transplantation. Ontological and pathway analysis indicates activation of ion transporters, which may relate to the growth advantage of transplanted fetal cells.

2023-04-27 | GSE201757 | GEO

Transcriptional comparison of Testicular Adrenal Rest Tumors with fetal and adult tissues

Project description:Transcriptional comparison of Testicular Adrenal Rest Tumors with fetal and adult tissues

| PRJNA806920 | ENA

T. oceanicus adult tissues

Project description:T. oceanicus adult tissues

| PRJEB27211 | ENA

Transcriptome analysis of fetal and adult liver samples

Project description:Genome wide expression analysis of 92 adult and 14 fetal liver samples

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Quantitative extracellular proteome analysis of fetal liver and adult bone marrow

Project description:We describe the proteomic composition of the extracellular environment of fetal and adult hematopoietic progenitors by data-independent acquisition mass spectrometry analysis.

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