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All-in-one Engineering Multifunctional Nanoplatforms for Sensitizing Tumor Low-Temperature Photothermal Therapy in vivo

ABSTRACT: All-in-one Engineering Multifunctional Nanoplatforms for Sensitizing Tumor Low-Temperature Photothermal Therapy in vivo

PROVIDER: PRJNA1026142 | ENA |

REPOSITORIES: ENA

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All-in-one Engineering Multifunctional Nanoplatforms for Sensitizing Tumor Low-Temperature Photothermal Therapy in vivo

Project description:To determine the effects of photothermal therapy on regulatory genes and molecular pathways of mouse triple negative breast cancer cells (4T1 cells), we studied the RNA sequences of 4T1 cells treated with medium (control), MoS2 NPs and MoS2 NPs + NIR (808 nm).

2023-10-11 | GSE244922 | GEO

Simultaneous multifunctional transcriptome engineering by CRISPR RNA scaffold

Project description:Simultaneous multifunctional transcriptome engineering by CRISPR RNA scaffold

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Network Landscape of Photothermal Flowering in Soybean.

Project description:The project aims at elucidation of global gene expression patterns underlying photothermal flowering of soybean to clarify the molecular mechanisms of photothermal flowering in soybean.

2021-07-25 | GSE117673 | GEO

Simultaneous multifunctional transcriptome engineering by CRISPR RNA scaffold

Project description:RNA processing and metabolism are subjected to precise regulation in the cell to ensure integrity and functions of RNA. Though targeted RNA engineering has become feasible with the discovery and engineering of the CRISPR-Cas13 system, simultaneous modulation of different RNA processing steps remains unavailable. In addition, the off-target events resulting from the effectors fused with dCas13 limit its application. Here we developed a novel platform, Combinatorial RNA Engineering via Scaffold Tagged gRNA (CREST), which can simultaneously execute multiple RNA modulation functions on different RNA targets. In CREST, RNA scaffolds are appended to the 3’ end of Cas13 gRNA and their cognate RNA binding proteins are fused with enzymatic domains for manipulation. We show that CREST is capable of simultaneously manipulating RNA alternative splicing and A-to-G or C-to-U base editing. Furthermore, by fusing two split fragments of the deaminase domain of ADAR2 to dCas13 and PUFc respectively, we reconstituted its enzyme activity at target sites. This split design can reduce more than 90% of off-target events otherwise induced by a full-length effector. The flexibility of the CREST framework will enrich the transcriptome engineering toolbox for the study of RNA biology and the development of RNA-focused therapeutics

2022-06-26 | GSE206745 | GEO

In situ Growth of ZIF-8 Nanoparticles on Graphene Oxide Nanosheets: A Multifunctional Nanoplatform for Combined Ion‐interference and Photothermal Therapy

Project description:In summary, highly stability and dispersed BSArGO@ZIF8 NSs were prepared by a simple electrostatic interaction method. According to the delivery effect of BSArGO@ZIF8 NSs, we found that BSArGO@ZIF8 NSs possess higher lethality to cancer cells. Furthermore, under NIR irradiation, BSArGO@ZIF8 NSs-mediated PTT could further kill cancer cells, and the increased temperature caused by photothermal conversion accelerated the Fenton reaction rate, enhancing the efficiency of BSArGO@ZIF8 NSs cell lethality. RNA-seq analysis confirmed that. BSArGO@ZIF8 NSs could promote cancer death through activate bim-mediated mitochondrial apoptotic events, induce disruption of microtubule function, loss of integrity of the nuclear membrane, DNA flagmentation, and change pro-apoptptic genes expression.

2023-12-01 | GSE191172 | GEO

In situ Growth of ZIF-8 Nanoparticles on Graphene Oxide Nanosheets: A Multifunctional Nanoplatform for Combined Ion‐interference and Photothermal Therapy

Project description:In situ Growth of ZIF-8 Nanoparticles on Graphene Oxide Nanosheets: A Multifunctional Nanoplatform for Combined Ion‐interference and Photothermal Therapy

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Network Landscape of Photothermal Flowering in Soybean.

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Photothermal Modulation of Human Stem Cells Using Light-responsive 2D Nanomaterials

Project description:Two-dimensional (2D) molybdenum disulfide (MoS2) nanomaterials are an emerging class of biomaterials that are photo-responsive at near-infrared wavelengths (NIR). Here, we demonstrate for the first time the ability of 2D MoS2 to modulate cellular functions of human stem cells through photothermal mechanisms. The interaction of MoS2 with human stem cells is investigated using whole transcriptome sequencing (RNA-seq). Global gene expression profile of stem cells reveals significant influence by NIR stimulation of MoS2 on integrins, cellular migration and wound healing. Overall, the combination of MoS2 and NIR light may provide new approach to control and regulate cellular migration and functions.

2020-06-29 | GSE141456 | GEO

Epigenetic Control of a Multifunctional Stress Regulator

Project description:Epigenetic Control of a Multifunctional Stress Regulator

| PRJNA504621 | ENA

Multifunctional Lanthanide-Doped Core/Shell Nanoparticles: Integration of Upconversion Luminescence, Temperature Sensing, and Photothermal Conversion Properties.

Project description:Multifunctional integration on single upconversion nanoparticles (UCNPs), such as the simultaneous achievement of imaging, sensing, and therapy, will be extremely attractive in various application fields. Herein, we demonstrated that single core/shell NaGdF4:Yb/Er-based UCNPs (<10 nm) with a highly Yb3+ or Nd3+ doped shell simultaneously exhibited good upconversion luminescence (UCL), temperature sensing, and photothermal conversion properties under 980 or 808 nm excitation, respectively. The spatial separation between the emission/sensing core and the heating shell was able to tailor the competition between the light and heat generation processes, and hence higher UCL efficiency and enhanced heating capability were achieved by introducing the rational core/shell design. Especially, Nd3+-sensitized core/shell nanoparticles were excitable to the laser at a more biocompatible wavelength of 808 nm, and hence the heating effect of water was greatly minimized. The heating and sensing capabilities of Nd3+-sensitized core/shell UCNPs with smaller sizes (<10 nm) were confirmed in aqueous environment under single 808 nm laser excitation, implying their promising applications in imaging-guided and temperature-monitored photothermal treatments.

| S-EPMC6641233 | biostudies-literature

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