Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – MADM-CloneSeq E10

ABSTRACT: Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – MADM-CloneSeq E10

PROVIDER: PRJNA1026948 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26359400.fastq.gz	Fastqsanger.gz
	SRR26359500.fastq.gz	Fastqsanger.gz
	SRR26359600.fastq.gz	Fastqsanger.gz
	SRR26359700.fastq.gz	Fastqsanger.gz
	SRR26359800.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 429

Similar Datasets

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – MADM-CloneSeq E10

Project description:The superior colliculus (SC) in the mammalian midbrain is essential for multisensory integration and is composed of a rich diversity of excitatory and inhibitory neurons and glia. The developmental principles directing the generation of SC cell-type diversity are however not understood. Here we pursued systematic cell lineage tracing in silico and in vivo, preserving full spatial information, using genetic MADM (Mosaic Analysis with Double Markers)-based clonal analysis with single-cell sequencing (MADM-CloneSeq). The analysis of clonally-related cell lineages revealed that radial glial progenitor (RGP) cells in SC are exceptionally multipotent. Individual resident RGPs have the capacity to produce all excitatory and inhibitory SC neuron types, even at the stage of terminal division. While individual clonal units show no pre-defined cellular composition, the establishment of appropriate relative proportions of distinct neuronal types occurs in a PTEN-dependent manner. Collectively, our findings provide an inaugural framework at single RGP/cell level of the mammalian SC ontogeny

2023-11-03 | GSE245102 | GEO

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – MADM-CloneSeq E12

Project description:Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – MADM-CloneSeq E12

| PRJNA1026947 | ENA

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – MADM-CloneSeq E12

2023-11-03 | GSE245103 | GEO

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

Project description:Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

| PRJNA1026945 | ENA

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – Pten

2023-11-03 | GSE245104 | GEO

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – Pten

Project description:Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – Pten

| PRJNA1026955 | ENA

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus - pooled embryonic Fzd10 lineage

2023-11-03 | GSE245105 | GEO

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus - pooled embryonic Fzd10 lineage

Project description:Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus - pooled embryonic Fzd10 lineage

| PRJNA1026954 | ENA

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-11-03 | GSE245106 | GEO

Expression analysis of MADM based glioma mouse model and normal brain

Project description:Mosaic Analysis with Double Markers (MADM) based glioma mouse model, which homozygously lacks Tp53 and Nf1, spontaneously developed gliomas at the post-natal 90-120 days. Tp53 and Nf1 are among the most frequently mutated genes in human glioma patients. Investigating the expression changes of genes induced by inactivation of Tp53, Nf1 and EZH2 can be a clue to clarify the mechanism of gliomagenesis. We examined the expressions of glioma cells in MADM mouse (n=2), EZH2 knocked-out MADM glioma tissues (n=3) and neural stem cell (NSC), astrocyte established with normal mice brains (n=2, respectively) and TP53 knocked-out astrocytes, derived from TP53 knocked-out mice (n=2). We used SurePrint G3 Mouse GE 8×60K array slides (G4858A, Agilent Technologies).

2020-02-20 | GSE110927 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data