Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-Sequencing of CD4, CD8 and CD19 splenocytes from mouse models of SLE

ABSTRACT: RNA-Sequencing of CD4, CD8 and CD19 splenocytes from mouse models of SLE

PROVIDER: PRJNA1028300 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26388247_1.fastq.gz	Fastqsanger.gz
	SRR26388247_2.fastq.gz	Fastqsanger.gz
	SRR26388248_1.fastq.gz	Fastqsanger.gz
	SRR26388248_2.fastq.gz	Fastqsanger.gz
	SRR26388249_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 54

Similar Datasets

RNA-Sequencing of CD4, CD8 and CD19 splenocytes from mouse models of SLE

Project description:Systemic Lupus Erythematosus (SLE) is an autoimmune disease that affects 20-150 out of 100,000 people globally. Reactive oxygen species (ROS) generation from mitochondrial dysfunction contributes to risk for SLE and autoimmune states and are potential targets for the treatment of autoimmunity. HRES-1/Rab4 (Rab4A) is a GTPase linked to mitochondrial oxidative stress and activation of the mechanistic target of rapamycin (mTOR), and has been linked to SLE pathogenesis. Here, RNA-sequencing (RNA-seq) was used to examine the expression of different classes of splenocytes (CD4+, CD8+, CD19+) from the lupus-prone SLE1.2.3. triple-congenic (B6.TC) mouse, as well as Rab4AQ72L mutant mice (which exhibits constitutive overexpression of Rab4a), and mice with CD4 T cell-specific deletion of Rab4A (KO).

2024-02-22 | GSE245413 | GEO

Expression data from CD4+ splenocytes 6h post-sepsis

Project description:Lymphocytes are adversely affected during sepsis. Some CD4+ splenocytes undergo apoptosis while others become Th2 polarized. The molecular determinants of these phenotypic changes are not known. Here we compare the transcriptional response of septic CD4 splenocytes to CD4 splenocytes from sham-manipulated animals 6h after sepsis and identify an early transcriptional component to the septic CD4+ splenocyte phenotype. We used microarrays to detail the global program of gene expression underlying the sepsis-induced changes in CD4+ splenocyte phenotype. Keywords: disease state analysis

2006-06-01 | GSE4479 | GEO

Microglia from a SLE models

Project description:Microglia from a SLE models

| PRJNA1090481 | ENA

SLE and atherosclerosis CD4+ T-cell RNAsequencing

Project description:Bulk RNAsequencing of CD4+ T-cells in SLE patients with (SLE-P) and without (SLE-NP) subclinical atherosclerotic plaques in carotid and femoral arteries, scanned by vascular ultrasound.

2024-10-10 | E-MTAB-13443 | biostudies-arrayexpress

Microglia from a SLE models

Project description:We isolated CD45+CD11b+ microglia from mouse models of SLE and their respective controls.

2024-04-25 | GSE262152 | GEO

RNA-seq from mice CD4+CD25+ splenocytes

Project description:RNA-seq from mice CD4+CD25+ splenocytes

| PRJNA858818 | ENA

RNA-seq from mice CD4+CD25+ splenocytes

Project description:To better understand the function of CD4+CD25+ splenocytes from different ages, target cells from young(8-week old) aged(18-month old) were sorted with magnetic beads. We then performed gene expression profiling analysis using data obtained from RNA-seq of different cells from different age.

2023-03-19 | GSE208231 | GEO

SLE and atherosclerosis CD4+ T-cell RNAsequencing

Project description:SLE and atherosclerosis CD4+ T-cell RNAsequencing

| PRJEB67538 | ENA

Investigation of gene expression profiles in CD4+ T cells from SLE patients and normal controls

Project description:To investigate the lncRNAs expression profiling in CD4+ T cells of systemic lupus erythematosus (SLE) patients, we have employed “Agilent Human lncRNA 4*180K microarray” as a discovery platform to identify lncRNAs and mRNAs expression signatures in CD4+ T cells between SLE patients and normal controls. CD4+ T cells were isolated from peripheral blood mononuclear cells (PBMCs) of peripheral blood in SLE patients and normal controls, respectively.

2021-08-05 | GSE181500 | GEO

Influence of genetic variation on inducible gene expression in murine CD4+ splenocytes.

Project description:Because activation of the immune response is dependent on extensive changes in gene expression, it is likely that a major component of inter-individual variation in the immune response is ultimately mediated at the level of gene regulation. Here, we examine the influence of genetic variation on inducible gene expression in the murine immune response. We extracted primary CD4 splenocytes from inbred strains A/J, C57BL/6J, BALB/c, DBA/2J, and 129x1/SvJ (3 animals/strain) and measured mRNA transcript levels using microarrays in both basal state and four hours after stimulation with PMA/Ionomycin. We report strain-specific genome-wide differences in mRNA expression between A/J, Balb/c, C57BL/6J, DBA/2J and 129X1/SvJ inbred mice in CD4 splenocytes in basal, stimulated (4hr, PMA/I) states.

2019-09-23 | GSE36551 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data