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Muscle epigenomic changes with once-weekly prednisone at 4- vs 24-months of age

ABSTRACT: Muscle epigenomic changes with once-weekly prednisone at 4- vs 24-months of age

PROVIDER: PRJNA1028600 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26401300_1.fastq.gz	Fastqsanger.gz
	SRR26401300_2.fastq.gz	Fastqsanger.gz
	SRR26401301_1.fastq.gz	Fastqsanger.gz
	SRR26401301_2.fastq.gz	Fastqsanger.gz
	SRR26401302_1.fastq.gz	Fastqsanger.gz

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Muscle epigenomic changes with once-weekly prednisone at 4- vs 24-months of age

Project description:this dataset encompasses the muscle GR epigenomic changes elicited in quadriceps muscles of 4- vs 24-month-old mice (males + females) with a 12-week-long regimen of once-weekly ZT0 prednisone (1mg/kg i.p.)

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muscle transcriptional changes with once-weekly prednisone at 4- vs 24-months of age

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muscle transcriptional changes with once-weekly prednisone at 4- vs 24-months of age

Project description:muscle transcriptional changes with once-weekly prednisone at 4- vs 24-months of age

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Project description:this dataset encompasses the cardiac GR epigenomic changes elicited in 4-month-old mice with a single ZT0 prednisone (1mg/kg i.p.) injection

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Myocardial KLF15 epigenomic changes with single ZT0 prednisone pulse

Project description:this dataset encompasses the cardiac KLF15 epigenomic changes elicited in 4-month-old mice with a single ZT0 prednisone (1mg/kg i.p.) injection

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muscle and white adipose tissue transcriptomes in obese WT mice after 12 weeks of prednisone regimens

Project description:Exogenous glucocorticoids regulate the muscl-fat axis communication, but little attention is paid to their frequency of intake. Here we investigated the transcriptional effects of prednisone in muscle and adipose tissue when dosed as intermittent once-weekly 1mg/kg i.p. versus once-daily 1mg/kg in WT obese mice. Prior to treatment, mice were fed a high-fat diet for 12 weeks. After 12 weeks of treatment, we performed RNA-seq analysis in muscle (quadriceps) and white adipose tissue (ventral fat pad) to quantitate gene expression at isoform level.

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sham and MI heart transcriptome after 6-week-long light-phase intermittent prednisone or vehicle administration

Project description:Exogenous glucocorticoids interact with the circadian clock, but little attention is paid to their time of intake. Here we investigated the transcriptional effects of prednisone in heart when pulsed as intermittent once-weekly 1mg/kg i.p. dose in WT mice at ZT0 at 2-weeks after sham or myocardial infarction (MI; permanent ligation) surgeries. Aftter 6 weeks of treatment, we performed RNA-seq analysis in myocardial tissue to quantitate gene expression at isoform level.

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Myocardial KLF15 epigenomic changes with single ZT0 prednisone pulse

Project description:Myocardial KLF15 epigenomic changes with single ZT0 prednisone pulse

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Myocardial GR epigenomic changes with single ZT0 prednisone pulse

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Muscle H3K27ac landscape remodeling with glucocorticoid steroid regimens

Project description:Duchenne muscular dystrophy is caused by genetic defects in the gene encoding dystrophin and leads to progressive muscle degeneration. Glucocorticoid steroids are current mainstay pharmacological regimen to decrease muscle inflammation and prolong the ambulatory period in these patients, but daily intake of glucocorticoids like prednisone and deflazacort causes adverse side effects like osteoporosis, adrenal suppression, insulin resistance and obesity. Intermittent steroid dosing has been proposed as alternative to maintain benefits and limit side effects, but a detailed understanding of the mechanisms underpinning the regimen-specific effects in muscle is still missing. Here we explore how once-daily versus once-weekly prednisone (4 week-long treatment) affect the epigenomic landscape in mdx mouse muscle (genetic model of Duchenne muscular dystrophy; DBA/2J background) through H3K27 acetylation profiles.

2019-11-30 | GSE137992 | GEO

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