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Knocking down the eIF4E gene in HaCaT cells, which M5 stimulates to establish the in vitro psoriasis cell model.

ABSTRACT: Knocking down the eIF4E gene in HaCaT cells, which M5 stimulates to establish the in vitro psoriasis cell model.

PROVIDER: PRJNA1038718 | ENA |

REPOSITORIES: ENA

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Knocking down the eIF4E gene in HaCaT cells, which M5 stimulates to establish the in vitro psoriasis cell model.

Project description:We transfected keratinocytes cell line (HaCaT cells) with si-NC and si-eIF4E, and added M5 into the cell culture medium to reveal the function of eIF4E in the in vitro psoriasis cell model.

2023-11-22 | GSE247463 | GEO

N6-methyladenosine (m6A) modification in HaCaT cells (immortalized human keratinocyte cell line) treated with STM2457 in the presence or absence of M5 (inflammatory factor cocktail) stimulation [MeRIPseq_KC]

Project description:We conducted an analysis of N6-methyladenosine (m6A) modifications in HaCaT cells, an immortalized human keratinocyte cell line, following treatment with METTL3 inhibitor, STM2457, under conditions of either M5 (inflammatory factor cocktail) stimulation or its absence. The primary aim of this investigation was to establish a molecular framework elucidating the role of m6A modifications in modulating the functional dynamics of keratinocytes within an inflammatory milieu.

2024-08-20 | GSE268746 | GEO

Whole Genome CGH array on patients with acute myeloid leukemia-M5 (AML-M5)

Project description:Unbalanced chromosomal abnormalities might play a major role in the leukemogenesis of AML-M5 Oligonucelotide array CGH were performed on 24 patients with AML-M5

2013-12-18 | GSE53429 | GEO

Whole Genome CGH array on patients with acute myeloid leukemia-M5 (AML-M5)

Project description:Unbalanced chromosomal abnormalities might play a major role in the leukemogenesis of AML-M5 Oligonucelotide array CGH were performed on 24 patients with AML-M5 To assess the possible existence of unbalanced chromosomal abnormalities and delineate the characterization of copy number alterations (CNAs) of acute myeloid leukemia-M5 (AML-M5)

2013-12-18 | E-GEOD-53429 | biostudies-arrayexpress

Saccharomyces cerevisiae M5 strain:M5

Project description:Saccharomyces cerevisiae M5 strain:M5 Genome sequencing and assembly

| PRJNA255314 | ENA

Pseudomonas sp. m5 strain:M5

Project description:Pseudomonas sp. m5 strain:M5 Genome sequencing and assembly

| PRJNA695736 | ENA

Arthrobacter sp. M5 strain:M5

Project description:Arthrobacter sp. M5 strain:M5 Genome sequencing and assembly

| PRJNA315169 | ENA

RNA-seq of C18-4 and TM4 cells samples from different M5 receptor modification groups

Project description:The goat of this project is to explore M5 receptor regulation spermatogenesis. We tried to search the mechanism of M5 receptor regulation spermatogenesis. RNA-seq of C18-4 and TM4 cells samples from different groups: C3NC, M5 knockdown in C18-4, TM3NC, M5 knockdown in TM4 cells. The cell were transfected with virus with inhibition of M5 expression ( M5 gene knockdown).

2021-06-16 | GSE142618 | GEO

C1 evolved adaptive clones M1-M5

Project description:Chemostat evolution experiment C1 under glucose-limited condition at 30C. Gene Expression profiles of adaptive clones M1-M5 in evolved conditions compared with original parents. An all pairs experiment design type is where all labeled extracts are compared to every other labeled extract. Genotype: Evolved clones. The genotype is not necessarily complete. Keywords: all_pairs Gene Expression profiles of adaptive clones M1-M5 in evolved conditions compared with original parents

2008-08-20 | E-GEOD-11071 | biostudies-arrayexpress

Discovery of a novel plant eIF4E-binding protein: Conserved Binding of eIF4E 1 (CBE1)

Project description:Regulation of translation initiation is accomplished in diverse eukaryotes through proteins which bind to the mRNA cap-binding protein, eIF4E, and either prevent its association with eIF4G or form repressive mRNPs which exclude the translation machinery. Such mechanisms in plants, and even the presence of eIF4E-interacting proteins outside of eIF4G (and the plant-specific isoform eIFiso4G, which binds eIFiso4E) which operate in a gene regulatory manner are not known. Here we describe the Conserved Binding of eIF4E 1 (CBE1), a plant-specific protein with an evolutionarily conserved eIF4E binding motif. This protein binds eIF4E or eIFiso4E in vitro to form cap-binding complexes, and is found as a constituent of cap-binding complexes in vivo in an eIF4E-dependent manner. Mutants lacking CBE1 show dysregulation of cell cycle related transcripts, accumulating higher levels relative to wild-type plants of mRNAs encoding proteins involved in mitotic processes. These findings support CBE1 as a plant protein with the capability to form cap-binding complexes with the potential for gene regulatory activity.

2018-09-26 | GSE114363 | GEO

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