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In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells

ABSTRACT: In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells

PROVIDER: PRJNA1039766 | ENA |

REPOSITORIES: ENA

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In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells

Project description:Carcinoma cells achieve malignant progression and therapy resistance through de-differentiation. While differentiation therapy has proven to be highly efficient in acute promyelocytic leukemia, this therapeutic strategy has not been successfully applied in human solid tumors. Here, we identify α-Glucosidase II (GANAB) as a novel driver of bladder cancer de-differentiation using a systemic biology approach and demonstrate its potential to serve as a therapeutic target of solid tumor differentiation therapy. Partial knock-out of GANAB by CRISPR Cas9 differentiates one of the most aggressive bladder carcinoma line into a non-invasive papillary form in vivo and decreases chemotherapy resistance in vitro. As differentiation and de-differentiation program are mostly activated in vivo, we labelled control and GANAB-KD cells with a lentivirus to express a H2B-EGFP localized in the nuclei. After sorting by BD FACS Aria II, cells were lyzed for RNA-sequencing.

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In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells [bulk]

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In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells [scRNA-Seq]

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In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells

Project description:In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells

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Project description:In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells [bulk]

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Project description:In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells [scRNA-Seq]

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RNA-Seq of circHIPK3 knockdown (KD) samples in UMUC3 and J82

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RNA-Seq of circCDYL knockdown (KD) samples in HepG2, J82, and UMUC3 cells and of GRWD1, IGF2BP1, and IGF2BP2 knockdown (KD) samples in J82 and UMUC3 cells

Project description:We profile gene expression upon circCDYL KD in HepG2 cells and in two bladder cancer cell lines J82 and UMUC3 as well as upon knockdown of the RNA binding proteins (RBP) GRWD1, IGF2BP1, and IGF2BP2 in J82 and UMUC3

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In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-31 | GSE164046 | GEO

RNA-Seq of circHIPK3 knockdown (KD) samples in UMUC3 and J82

Project description:RNA-Seq of circHIPK3 knockdown (KD) samples in UMUC3 and J82

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