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In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells

ABSTRACT: In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells

PROVIDER: PRJNA688703 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13329925.fastq.gz	Fastqsanger.gz
	SRR13329926.fastq.gz	Fastqsanger.gz
	SRR13329927.fastq.gz	Fastqsanger.gz
	SRR13329928.fastq.gz	Fastqsanger.gz
	SRR13329929.fastq.gz	Fastqsanger.gz

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In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells [bulk]

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Project description:Carcinoma cells achieve malignant progression and therapy resistance through de-differentiation. While differentiation therapy has proven to be highly efficient in acute promyelocytic leukemia, this therapeutic strategy has not been successfully applied in human solid tumors. Here, we identify α-Glucosidase II (GANAB) as a novel driver of bladder cancer de-differentiation using a systemic biology approach and demonstrate its potential to serve as a therapeutic target of solid tumor differentiation therapy. Partial knock-out of GANAB by CRISPR Cas9 differentiates one of the most aggressive bladder carcinoma line into a non-invasive papillary form in vivo and decreases chemotherapy resistance in vitro. As differentiation and de-differentiation program are mostly activated in vivo, we labelled control and GANAB-KD cells with a lentivirus to express a H2B-EGFP localized in the nuclei. After sorting by BD FACS Aria II, cells were lyzed for RNA-sequencing.

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In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells [scRNA-Seq]

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In vivo transcriptome profiling of control and GANAB-KD UMUC3 bladder carcinoma cells

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:RNA-Seq of circCDYL knockdown (KD) samples in HepG2, J82, and UMUC3 cells and of GRWD1, IGF2BP1, and IGF2BP2 knockdown (KD) samples in J82 and UMUC3 cells

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