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Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells I

ABSTRACT: Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells I

PROVIDER: PRJNA1045602 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26965576_1.fastq.gz	Fastqsanger.gz
	SRR26965576_2.fastq.gz	Fastqsanger.gz
	SRR26965577_1.fastq.gz	Fastqsanger.gz
	SRR26965577_2.fastq.gz	Fastqsanger.gz
	SRR26965578_1.fastq.gz	Fastqsanger.gz

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Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells III

Project description:The gut microbiota promotes immune system development in early life, but the interactions between the gut metabolome and immune cells in the neonatal gut remains largely undefined. Here, we demonstrate that the neonatal gut is uniquely enriched with neurotransmitters, including serotonin; specific gut bacteria produce serotonin directly while downregulating monoamine oxidase A to limit serotonin breakdown. Serotonin directly signals to T cells to increase intracellular indole-3-acetaldehdye to inhibit mTOR activation and thereby promotes the differentiation of regulatory T cells, both ex vivo and in vivo in the neonatal intestine. Oral gavage of serotonin into neonatal mice leads to long-term T cell-mediated antigen-specific immune tolerance towards both dietary antigens and commensal bacteria. Together, our study has uncovered an important role for unique gut bacteria to increase serotonin availability in the neonatal gut and a novel function of gut serotonin to shape T cell response to dietary antigens and commensal bacteria to promote immune tolerance in early life.

2024-01-31 | GSE248692 | GEO

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells II

2024-01-31 | GSE248691 | GEO

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells I

2024-01-31 | GSE248690 | GEO

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells

Project description:Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells

| PRJNA1045606 | ENA

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells II

Project description:Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells II

| PRJNA1045601 | ENA

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells III

Project description:Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells III

| PRJNA1045603 | ENA

Serotonin signals through a gut-liver axis to regulate hepatic steatosis

Project description:Purpose: While various functions of peripheral serotonin are known, the direct role of serotonin in regulating hepatic lipid metabolism in vivo is not well understood. We studied whether serotonin directly acts on liver to regulate lipid metabolism. Methods: Methods: 12 weeks aged liver-specific Htr2a KO (Albumin-Cre+/-; Htr2aflox/flox, herein named Htr2a LKO) mice and wildtype (WT) littermates were fed a high-fat diet (HFD, 60% fat calories) for 8 weeks. Results: Hepatic lipid droplet accumulation, NAFLD activity score, and hepatic triglyceride levels were dramatically reduced in HFD-fed Htr2a LKO mice compared to WT littermates. Conclusions: Gut-derived serotonin is a direct regulator of hepatic lipid metabolism via a gut TPH1-liver HTR2A endocrine axis. And shows promise as a novel drug target to ameliorate NAFLD with minimal systemic metabolic effects.

2018-11-27 | GSE120662 | GEO

Early life myeloid immune cells in the neonatal liver

Project description:The translocation of macromolecules across the mammalian intestinal epithelial barrier is enhanced in early life before ceasing at what has been termed gut closure. However, the translocated macromolecules, the mechanism of translocation, and the functional consequences for the neonatal liver, which is still a hematopoietic organ at this age in mice, have not been defined. Microbiota profiling identified a transiently increased abundance of small intestinal lipopolysaccharide (LPS)-producing g-Proteobacteria early after birth. Orally administered LPS was translocated across the mucosal barrier during this early postnatal window, resulting in increased hepatic cytokine expression. LPS translocation was independent of disabled homolog 2 (Dab2)-mediated endocytosis by fetal-like enterocytes, but was mediated by the fatty acid translocase CD36, which showed transient overexpression early after birth. Postnatal LPS exposure altered hepatic haematopoiesis, innate immune reactivity and the bacterial clearance capacity of the neonatal liver. Taken together, our results identify and characterise a postnatal time window of hepatic tissue stimulation by gut-derived LPS as a novel immune priming event in early life.

2024-12-22 | GSE282969 | GEO

Gut bacteria-derived serotonin promotes immune tolerance in early life through regulation of neonatal gut T cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-31 | GSE248694 | GEO

Neonatal Gut Metagenomes

Project description:Neonatal gut-microbiome-derived 12,13 DiHOME impedes tolerance and predicts childhood atopy and asthma

| PRJEB24006 | ENA