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Assessing the Impact of STX4 Knockdown on the Transcriptome of Brown Adipose Tissue

ABSTRACT: Assessing the Impact of STX4 Knockdown on the Transcriptome of Brown Adipose Tissue

PROVIDER: PRJNA1045675 | ENA |

REPOSITORIES: ENA

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Assessing the Impact of STX4 Knockdown on the Transcriptome of Brown Adipose Tissue

Project description:In this study, we investigate the effects of Syntax 4 (STX4) knockdown in brown adipocytes and its role in age-related changes in brown adipose tissue (BAT). Our focus was to understand the mechanisms preceding the significant loss of BAT mass observed with aging. By comparing transcriptomic profiles before the onset of this massive tissue loss, we identified a notable increase in markers indicative of pyroptotic cell death. These findings suggest a potential link between STX4 activity, cellular death pathways, and age-related alterations in BAT, providing insights into the molecular underpinnings of BAT aging and loss.

2024-02-24 | GSE248733 | GEO

ClariomS Array to Investigate Vaspin Transgenic Mice: Assessing the Impact of (Brown) Adipocyte Vaspin Expression on Thermoregulation and Brown Adipose Tissue Thermogenesis

Project description:Vaspin previously was identified as part of the secretome of activated brown adipose tissue in mice. For microarray analysis and to determine the effect of adipocyte-sepcific vaspin overexpression on transcriptional changes during acute cold exposure, brown adipose tissue of female vaspin transgenic mice on C57BL/6N background (published in 10.3389/fendo.2023.1146454; VasTg) and wild type control mice were investigated after acute 6 h cold exposure of 8°C.

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Brown Adipose Tissue

Project description:Brown Adipose Tissue

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Bulk mRNA-seq of brown adipose tissue derived from SLC25A44 knockdown mouse

Project description:We generated dCas9-KRAB (dK) Tg mice and gRNA targeting Slc25a44 Tg mice. Slc25a44 knockdown mice were obtained by crossing these two Tg mice. Brown adipose tissue from Slc25a44 KD mice (dK+;gRNA+) and littermate control mice (either dK+ or gRNA+) were collected and subjected to transcriptome profiling by RNA-seq.

2019-07-12 | E-MTAB-7987 | biostudies-arrayexpress

Prdm16 Knockout Brown Adipose Tissue

2014-04-09 | GSE55080 | GEO

Prdm16 Knockout Brown Adipose Tissue

Project description:Gene expression profile from brown adipose tissues of Prdm16 knockout and wile type mice. Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and beige adipocytes. However, whether Prdm16 is required for the development or physiological function of brown adipose tissue (BAT) in vivo has been unclear. By analyzing mice that selectively lacked Prdm16 in the brown adipose lineage, we found that Prdm16 was dispensable for embryonic BAT development. Brown adipose tissues were collected from Prdm16 knockout and wiletype mice with 4 biological replicates per condition. Experiment was done in two separate batch for 6-week-old and 11-month-old. Extracted RNA was hybridized to Agilent two-color arrays.

2014-04-09 | E-GEOD-55080 | biostudies-arrayexpress

Brown versus white tissue adipose selective genes

2007-06-08 | GSE8044 | GEO

LC-MS/MS proteomic analysis of mouse brown adipose tissues

Project description:This project aims to identify the proteins present in RNA granules of brown adipose tissue upon exposure to cold challenge. Wild type C57BL/6J mice were born and raised at thermoneutrality and were then subjected to cold exposure for 90 minutes. Brown adipose tissues were collected, and the protein lysates of RNA granules isolated from the brown adipose tissues were separated using SDS-PAGE gels and visualized with Coomassie stain. The protein bands were subsequently excised for downstream sample processing.

2023-11-23 | PXD044433 | Pride

Transcription profiling of mouse brown versus white tissue adipose

Project description:The aim of this study was to identify genes expressed selectively in brown adipose tissue as compared to white adipose tissue from the same animals. This analysis provides a gene set that is brown and white adipose selective. Experiment Overall Design: Interscapular brown adipose tissue and epididymal white adipose tissue was carefully dissected from 3 male C57Bl/6 mice. These samples were profiled independently using Affymetrix mouse 430_2 gene arrays, representing 3 biological replicates for each brown and white adipose tissues.

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Analysis of gene expression patterns in brown adipose tissue

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2024-07-22 | GSE269003 | GEO

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