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Assessing the Impact of STX4 Knockdown on the Transcriptome of Brown Adipose Tissue

ABSTRACT: Assessing the Impact of STX4 Knockdown on the Transcriptome of Brown Adipose Tissue

PROVIDER: PRJNA1045675 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26961420_1.fastq.gz	Fastqsanger.gz
	SRR26961420_2.fastq.gz	Fastqsanger.gz
	SRR26961421_1.fastq.gz	Fastqsanger.gz
	SRR26961421_2.fastq.gz	Fastqsanger.gz
	SRR26961422_1.fastq.gz	Fastqsanger.gz

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Assessing the Impact of STX4 Knockdown on the Transcriptome of Brown Adipose Tissue

Project description:In this study, we investigate the effects of Syntax 4 (STX4) knockdown in brown adipocytes and its role in age-related changes in brown adipose tissue (BAT). Our focus was to understand the mechanisms preceding the significant loss of BAT mass observed with aging. By comparing transcriptomic profiles before the onset of this massive tissue loss, we identified a notable increase in markers indicative of pyroptotic cell death. These findings suggest a potential link between STX4 activity, cellular death pathways, and age-related alterations in BAT, providing insights into the molecular underpinnings of BAT aging and loss.

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Brown Adipose Tissue

Project description:Brown Adipose Tissue

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Bulk mRNA-seq of brown adipose tissue derived from SLC25A44 knockdown mouse

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Prdm16 Knockout Brown Adipose Tissue

Project description:Gene expression profile from brown adipose tissues of Prdm16 knockout and wile type mice. Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and beige adipocytes. However, whether Prdm16 is required for the development or physiological function of brown adipose tissue (BAT) in vivo has been unclear. By analyzing mice that selectively lacked Prdm16 in the brown adipose lineage, we found that Prdm16 was dispensable for embryonic BAT development. Brown adipose tissues were collected from Prdm16 knockout and wiletype mice with 4 biological replicates per condition. Experiment was done in two separate batch for 6-week-old and 11-month-old. Extracted RNA was hybridized to Agilent two-color arrays.

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