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ABSTRACT: Whole-genome sequence data for 8 heterogeneous stock rat founders

PROVIDER: PRJNA1048943 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR27117008.fastq.gz	Fastqsanger.gz
	SRR27117008_1.fastq.gz	Fastqsanger.gz
	SRR27117008_2.fastq.gz	Fastqsanger.gz
	SRR27117009.fastq.gz	Fastqsanger.gz
	SRR27117009_1.fastq.gz	Fastqsanger.gz

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Project description:These Heterogeneous Stock (HS) rats are derived from eight inbred progenitors through more than 60 generations of outbreeding. As a result they are fine-grained mosaics of the founder genomes, and well suited for high-resolution genetic mapping of complex traits. This experiment provides dense genotyping data for 1407 HS rats, 15 duplicates, and the 8 progenitors. From these data, each HS rat chromosome can be reconstructed as a mosaic of progenitor haplotypes. Together with phenotype and sequence data available elsewhere (DOI:10.1038/ng.2644), these data allowed fine-mapping of 160 complex traits, and identified causal genes at the QTLs. The sequences of the progenitors are available from ENA (study accession PRJEB3358, http://www.ebi.ac.uk/ena/data/view/PRJEB3358). A series of supporting data files are available from http://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2332 , with an accompanying list (suppl_files_description.xlsx) describing each supporting file.

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