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Expression data from cultured spermatogonia established from Cdkn1c conditional knockout mouse testes

ABSTRACT: Expression data from cultured spermatogonia established from Cdkn1c conditional knockout mouse testes

PROVIDER: PRJNA1065281 | ENA |

REPOSITORIES: ENA

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Expression data from cultured spermatogonia established from Cdkn1c conditional knockout mouse testes

Project description:Mice lacking Cdkn1c (p57) in spermatogonia were found to be congenitally infertile due to spermatogonia depletion. Transplantation experiments showed that Cdkn1c deficiency compromised spermatogonial stem cells (SSC) activity. SSCs undergo self-renewal division to sustain spermatogenesis, and it is possible to derive germline stem (GS) cell cultures by supplementing GDNF and FGF2. We examined the influence of Cdkn1c depletion on gene expression of GS cells. In this dataset, we include the expression data obtained from cultured spermatogonia (GS cells) derived from Cdkn1c(p57) floxed/floxed mice. Cdkn1c(p57) floxed/floxed GS cells were treated with adenovirus cre recombinase. Each group contains 3 biological replicates.

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Gene expression analysis of human cell lines established from normal patient's fibroblast and BWS patients with known mutations in the CDKN1C and KCNQ1OT1

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