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A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation [CUT&RUN]

ABSTRACT: A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation [CUT&RUN]

PROVIDER: PRJNA1065308 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27561750_1.fastq.gz	Fastqsanger.gz
	SRR27561750_2.fastq.gz	Fastqsanger.gz
	SRR27561751_1.fastq.gz	Fastqsanger.gz
	SRR27561751_2.fastq.gz	Fastqsanger.gz
	SRR27561752_1.fastq.gz	Fastqsanger.gz

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A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation [CUT&RUN]

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Project description:Here we describe successful implementation of CUT&RUN for profiling protein-DNA interactions in zebrafish embryos. We apply modified a CUT&RUN method to generate high resolution maps of enrichment for H3K4me3, H3K27me3, H3K9me3, and RNA polymerase II during zebrafish gastrulation. Using this data, we identify a conserved subset of developmental genes that are enriched in both H3K4me3 and H3K27me3 during gastrulation, and we demonstrate the increased effectiveness of CUT&RUN for detecting protein enrichment at repetitive sequences with reduced mappability. Our work demonstrates the power of combining CUT&RUN with the strengths of the zebrafish system to better understand the changing embryonic chromatin landscape and its roles in shaping development.

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