Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential usage of shared binding sites drives functional specialization of an essential family of transcription factors [ChIP-seq]

ABSTRACT: Differential usage of shared binding sites drives functional specialization of an essential family of transcription factors [ChIP-seq]

PROVIDER: PRJNA1066755 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27663851.fastq.gz	Fastqsanger.gz
	SRR27663852.fastq.gz	Fastqsanger.gz
	SRR27663853.fastq.gz	Fastqsanger.gz
	SRR27663854.fastq.gz	Fastqsanger.gz
	SRR27663855.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 31

Similar Datasets

Differential usage of shared binding sites drives functional specialization of an essential family of transcription factors

Project description:Differential usage of shared binding sites drives functional specialization of an essential family of transcription factors

| PRJNA1066744 | ENA

Differential usage of shared binding sites drives functional specialization of an essential family of transcription factors [RNA-seq]

Project description:Differential usage of shared binding sites drives functional specialization of an essential family of transcription factors [RNA-seq]

| PRJNA1066754 | ENA

Differential usage of shared binding sites drives functional specialization of an essential family of transcription factors [RNA-seq]

Project description:Throughout evolution, the duplication and functional divergence of transcription factors (TFs) has driven cellular and organismal complexity. Mechanisms by which paralogous TFs functionally diverge are thus of broad interest yet remain poorly understood. One well-established mechanism underlying TF divergence is the occupation and regulation of distinct sets of genes. Here we test for new mechanisms using CORONA (CNA) and PHABULOSA (PHB), two representative members of the CLASS III HOMEODOMAIN LEUCINE ZIPPER (HD-ZIPIII) family of plant TFs. CNA and PHB have largely overlapping binding profiles yet each paralog has hundreds of uniquely regulated targets. Regulation of a given gene thus depends on whether its local binding site is considered primed (inactive) or regulated (active) by CNA or PHB. This decision appears to be controlled, at least in part, by their lipid binding START domain, proposing a model in which HD-ZIPIII TFs use information integrated by their START domain to generate paralog-specific transcriptional outcomes at commonly bound genes. Taken together, our study identifies a new mechanism of TF paralog divergence and proposes the ubiquitously distributed START evolutionary module as a driver of functional divergence.

2024-10-08 | GSE253674 | GEO

Differential usage of shared binding sites drives functional specialization of an essential family of transcription factors [ChIP-seq]

2024-10-08 | GSE253671 | GEO

Differential usage of shared binding sites drives functional specialization of an essential family of transcription factors

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-07 | GSE253676 | GEO

Gene Expression Signature Shared in Autoimmune Diseases Not in Unaffected Family Members

Project description:Even though autoimmune diseases are heterogeneous, believed to result from the interaction between genetic and environmental components, patients with these disorders exhibit reproducible patterns of gene expression in their peripheral blood mononuclear cells. A portion of this gene expression profile reflects family resemblance rather than the actual presence of an autoimmune disease. Here we wanted to identify that portion of this gene expression pattern that is independent of family resemblance and determine if it is a product of disease duration, disease onset, or other factors. By increasing the number of autoimmune samples in our analysis and employing supervised clustering algorithms, we identified 100 genes whose expression profiles are shared in individuals with various autoimmune diseases but are not shared by first-degree relatives of individuals with autoimmune disease or by controls. Individuals with early disease (1 yr after onset) and established disease (10 yr after onset) exhibit a near identical expression pattern suggesting that this unique profile reflects disease onset rather than disease duration. supervised gene expression profiling were performed to a cohort sample pool: control individuals(8), unaffected family members of autoimmune diseases patients (8), and individuals with autoimmune diseases (54). we try to identify a gene expression signatures that were exclusively associated with autoimmune diseases but not infulenced by genetic components

2010-06-30 | E-GEOD-3447 | biostudies-arrayexpress

Specialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export

Project description:Specialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export

| PRJNA551689 | ENA

Shared αβ T Cell Receptor Usage in Lungs of Sarcoidosis Patients with Löfgren’s Syndrome

Project description:Shared αβ T Cell Receptor Usage in Lungs of Sarcoidosis Patients with Löfgren’s Syndrome

| PRJNA392108 | ENA

Subsoil specialization

Project description:Subsoil specialization in arbuscular mycorrhizal fungi

| PRJEB25819 | ENA

Gene Expression Signature Shared in Autoimmune Diseases Not in Unaffected Family Members

2005-10-15 | GSE3447 | GEO