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CAMKV geneknockown induces transcriptomic changes in neuroblastoma cell line NGP

ABSTRACT: CAMKV geneknockown induces transcriptomic changes in neuroblastoma cell line NGP

PROVIDER: PRJNA1076170 | ENA |

REPOSITORIES: ENA

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CAMKV geneknockown induces transcriptomic changes in neuroblastoma cell line NGP

Project description:To investigate the effect of CAMKV knockdown on transcriptomic profiling in neuroblastoma and delineate the role of CAMJV in neuroblastoma growth. We knockdowned the gene exprssion of CAMKV in NGP cells and performed gene expression profiling analysis using data obtained from RNA-seq.

2024-10-24 | GSE255691 | GEO

ERK inhibitor, ulixertinib induces transcriptomic changes in NGP cells

Project description:To investigate the effect of ERK inhibitor, ulixertinib, on NB cell proliferation and delineate the mechanisms of ulixertinib-mediated ERK pathway inhibition in NB. We treated human neuroblastoma cell line, NGP with ulixertinib and performed gene expression profiling analysis using data obtained from RNA-seq.

2023-03-01 | GSE213153 | GEO

CAMKV inhibitor, OTSSP167 induces transcriptomic changes in NGP cells

Project description:To investigate the effect of CAMKV inhibitor, OTSSP167, on NB cell proliferation and delineate the mechanisms of CAMKV-mediated pathway inhibition in NB. We treated human neuroblastoma cell line, NGP with OTSSP167 and performed gene expression profiling analysis using data obtained from RNA-seq.

2024-10-24 | GSE255692 | GEO

ERK inhibitor, ulixertinib induces transcriptomic changes in NGP cells

Project description:ERK inhibitor, ulixertinib induces transcriptomic changes in NGP cells

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CAMKV inhibitor, OTSSP167 induces transcriptomic changes in NGP cells

Project description:CAMKV inhibitor, OTSSP167 induces transcriptomic changes in NGP cells

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Identification of SOX11 binding sites through CUT&RUN sequencing in the neuroblastoma cell lines IMR-32, CLB-GA, NGP and SH-EP

Project description:CUT&RUN sequencing to define binding sites for SOX11 and IgG in the neuroblastoma cell lines IMR-32, CLB-GA and NGP as well as neuroblastoma cell line SH-EP after SOX11 overexpression for 48h. A SOX11 inducible overexpression system was generated using a Tet-on system.

2022-12-13 | E-MTAB-11905 | biostudies-arrayexpress

Expression data of neuroblastoma tissues, spheres and NGP cell line overexpressing CFC1

Project description:Expression data of neuroblastoma tissues, spheres and NGP cell line overexpressing CFC1

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Expression data of CFC1 overexpressed neuroblastoma cell line, NGP

Project description:We performed a microarray analysis on CFC1-expressing NGP cells. Expression data in CFC1- and mock-NGP cells were generated and compared. Differentially expressed genes (DEGs) were functionally annotated by a pathway analysis and Gene Set Enrichment Analysis (GSEA). Both analyses showed that genes involved in “differentiation”, “oncogene-induced senescence”, “stem cell proliferation” and “Activin signaling” pathways were significantly enriched in DEGs. “TGFbeta pathway” and “Nodal pathway” were also enriched in the GeneSpring GX pathway analysis, but were not significant in the GSEA analysis. This result suggests that the pathways involved in cell stemness and Activin signaling were enhanced by the expression of CFC1 in NB cells accompanied by transcriptional changes in their related gene members.

2017-12-01 | GSE90790 | GEO

RNA-seq of human CLB-GA and NGP neuroblastoma cell lines with SOX11 knockdown as compared to control

Project description:RNA-seq upon SOX11 knockdown in the neuroblastoma cell lines CLB-GA and NGP. Cells were nucleofected with a pool of four different siRNAs targeting SOX11 and a non-targeting control (NTC). Analysis was performed 2 days upon SOX11 knockdown, including four biological replicates per condition.

2022-12-13 | E-MTAB-11883 | biostudies-arrayexpress

Reversible LSD1 Inhibition with HCI-2509 induces the p53 gene expression signature in high-risk neuroblastoma cells

Project description:Lysine-Specific Demethylase 1 (LSD1) over-expression correlates with poorly differentiated neuroblastoma and predicts poor outcome despite multimodal therapy. We have studied the efficacy of reversible and specific LSD1 inhibition with HCI-2509 in neuroblastoma cell lines and particularly the effect of HCI-2509 on the transcriptomic profile in MYCN amplified NGP cells. Cell survival assays show that HCI-2509 is cytotoxic to poorly differentiated neuroblastoma cell lines in low micromole or lower doses. Transcriptional profiling of NGP cells treated with HCI-2509 shows a significant effect on p53, cell cycle, MYCN and hypoxia pathway gene sets. HCI-2509 results in increased histone methyl marks and p53 levels along with cell cycle arrest in the G2/M phase and inhibition of colony formation of NGP cells. Our findings indicate that LSD1 inhibition with HCI-2509 has a multi-target effect in MYCN amplified high-risk neuroblastoma cells.

2019-01-01 | GSE104526 | GEO

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