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Expression profiling of mouse livers with inducible over-expression of microRNA Mir483

ABSTRACT: Expression profiling of mouse livers with inducible over-expression of microRNA Mir483

PROVIDER: PRJNA1078900 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28038219_1.fastq.gz	Fastqsanger.gz
	SRR28038219_2.fastq.gz	Fastqsanger.gz
	SRR28038220_1.fastq.gz	Fastqsanger.gz
	SRR28038220_2.fastq.gz	Fastqsanger.gz
	SRR28038221_1.fastq.gz	Fastqsanger.gz

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Expression profiling of mouse livers with inducible over-expression of microRNA Mir483

Project description:In this study we generated mice with inducible over-expression of microRNA Mir483, using a transgene inserted at the Rosa26 locus. Whole transcriptome analysis was performed by RNA-seq in livers collected from 15-week old adult mice (over-expressors and controls).

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MicroRNA expression profiles in livers during pigeon (Columba livia) development

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Predictive and Prognostic Value of Inflammatory Markers and microRNA in Stage IV Colorectal Cancer

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ChIP-seq of livers in control and Cnot1 tamoxifen-inducible liver-specific knockout mice

Project description:Gene expression is balanced by transcription and mRNA degradation. Shortening of polyadenosine (poly(A)) tails (deadenylation) is the initial step in the decay of most mRNAs. However, the mechanism by which deadenylation controls mRNA expression is not fully understood. This experiment aimed to determine changes in transcriptional activity in livers of control and Cnot1 tamoxifen-inducible liver-specific knockout mice. Control and Cnot1 tamoxifen-inducible liver-specific knockout mice placed on tamoxifen-containing food at 6 weeks of age for 2 weeks. Lysates from livers were subjected to ChIP assay with Histone H3 (tri methyl K4) (H3K4me3) antibody (ab8580; abcam) using SimpleChIP Enzyatic Chromatin IP Kit (#9003; Cell Signaling Technology). Libraries for DNA sequence were prepared from DNA isolated by ChIP assays with a KAPA Hyper Prep Kit (Illumina). 109 base-pair pair-end read DNA-seq was performed with Hiseq PE Rapid Cluster Kit v2-HS and Hiseq Rapid SBS Kit v2-HS (200 Cycle) on Illumina Hiseq2500.

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Global microRNA expression profiling of mouse livers following ischemia-reperfusion injury at different stages

Project description:Global microRNA expression profiling of mouse livers following ischemia-reperfusion injury at different stages

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Global microRNA expression profiling of mouse livers following ischemia-reperfusion injury at different stages. [miRNA]

Project description:Hepatic ischemia reperfusion injury is a dynamic process consisting of two stages: ischemia and reperfusion, and triggers a cascade of physiological and biochemical events. Given the important role of microRNAs in regulating gene expression, we analyzed gene expression changes in mouse livers at sham control, ischemia stage, and reperfusion stage. We generated global expression profiles of microRNA and mRNA genes in mouse livers subjected to ischemia reperfusion injury at the three stages, respectively. Comparison analysis showed that reperfusion injury had a distinct expression profile whereas the ischemia sample and the sham control were clustered together. Consistently, there are 69 differentially expressed microRNAs between the reperfusion sample and the sham control whereas 28 differentially expressed microRNAs between the ischemia sample and the sham control. We further identified two modes of microRNA expression changes in ischemia reperfusion injury. Functional analysis of both the differentially expressed microRNAs in the two modes and their target mRNAs revealed that ischemia injury impaired mitochondria function, nutrient consumption, and metabolism process. In contrast, reperfusion injury led to severe tissue inflammation that is predominantly an innate-immune response in the ischemia reperfusion process. Our staged analysis of gene expression profiles provides new insights into regulatory mechanisms of microRNAs in mouse hepatic ischemia reperfusion injury.

2015-10-01 | GSE72314 | GEO

Global microRNA expression profiling of mouse livers following ischemia-reperfusion injury at different stages. [mRNA]

2015-10-01 | GSE72312 | GEO

MicroRNA expression in Snd1 KO mouse liver

Project description:The RNA-binding protein Snd1 can regulate gene expression through various mechanisms, including microRNA decay. Here we have investigated microRNA expression in livers of WT and Snd1 knockout (KO) mice

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GNPS - Ace Over Expression in Mice Targeted Metabolomics Study

Project description:Over-expression of angiotensin converting enzyme in mouse neutrophils and macrophages producing phenotypic changes in metabolism.

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