Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Holt-Oram syndrome at single cell resolution

ABSTRACT: Holt-Oram syndrome at single cell resolution

PROVIDER: PRJNA1084824 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Holt-Oram syndrome at single cell resolution

Project description:Holt-Oram syndrome (HOS), characterized by heart and forelimb defects, is caused by mutations in the T-box transcription factor, TBX5. While much has been done to elucidate TBX5’s transcriptional mechanisms in animal and human induced pluripotent stem cell (iPSC) models, transcriptomics from HOS patient tissue is lacking.

2024-12-16 | GSE261014 | GEO

MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome [array]

Project description:The regulative role of miRNAs in Holt-Oram Syndrome is investigated in a zebrafish model.

2015-10-01 | GSE69578 | GEO

MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome [miRNA-seq]

Project description:The regulative role of miRNAs in Holt-Oram Syndrome is investigated in a zebrafish model.

2015-10-01 | GSE69690 | GEO

Discovering miRNA regulatory networks in Holt-Oram Syndrome using a Zebrafish model [array]

Project description:To investigate the complex regulatory networks disrupted in Holt-Oram Syndrome, we characterized genome-widely the miRNA and mRNA expression profiles in WT and Tbx5 depleted zebrafish embryos at two development time points, 24 and 48 hpf.

2016-04-24 | GSE64426 | GEO

Discovering miRNA regulatory networks in Holt-Oram Syndrome using a Zebrafish model [miRNA-seq]

2016-04-24 | GSE64465 | GEO

Decoding the endometrial niche of Asherman's syndrome at single-cell resolution

Project description:Decoding the endometrial niche of Asherman's syndrome at single-cell resolution

| PRJNA891357 | ENA

Decoding the endometrial niche of Asherman's syndrome at single-cell resolution [organoids]

Project description:Decoding the endometrial niche of Asherman's syndrome at single-cell resolution [organoids]

| PRJNA895089 | ENA

Discovering miRNA regulatory networks in Holt-Oram Syndrome using a Zebrafish model

Project description:Discovering miRNA regulatory networks in Holt-Oram Syndrome using a Zebrafish model

| PRJNA271069 | ENA

Normal and Sjogren’s syndrome models of the murine lacrimal gland studied at single-cell resolution

Project description:Normal and Sjogren’s syndrome models of the murine lacrimal gland studied at single-cell resolution

| PRJNA548013 | ENA

Decoding the endometrial niche of Asherman's syndrome at single-cell resolution

Project description:Asherman’s Syndrome is characterized by intrauterine adhesions or scarring, which cause infertility, menstrual abnormalities, and recurrent pregnancy loss. The pathophysiology of this syndrome remains unknown, with treatment restricted to recurrent surgical removal of intrauterine scarring, which has limited success. Here, we decode the Asherman’s Syndrome endometrial cell niche by analyzing data from over 200,000 cells with single-cell RNA-sequencing in patients with this condition and through in vitro analyses of Asherman’s Syndrome patient-derived endometrial organoids. Our endometrial atlas highlights the loss of the endometrial epithelium, alterations to epithelial differentiation signaling pathways such as Wnt and Notch, and the appearance of characteristic epithelium expressing secretory leukocyte protease inhibitor during the window of implantation. We describe syndrome-associated alterations in cell-to-cell communication and gene expression profiles that support a dysfunctional pro-fibrotic, pro-inflammatory, and anti-angiogenic environment.

2023-08-03 | GSE215968 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data