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Spatial transcriptomic of EAT and Atrial appendage from patienst with Atrial Fibrillation

ABSTRACT: Spatial transcriptomic of EAT and Atrial appendage from patienst with Atrial Fibrillation

PROVIDER: PRJNA1086563 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28293500_1.fastq.gz	Fastqsanger.gz
	SRR28293500_2.fastq.gz	Fastqsanger.gz
	SRR28293600_1.fastq.gz	Fastqsanger.gz
	SRR28293600_2.fastq.gz	Fastqsanger.gz
	SRR28293501_1.fastq.gz	Fastqsanger.gz

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Spatial transcriptomic of EAT and Atrial appendage from patienst with Atrial Fibrillation

Project description:To examine biological changes and regionality dictating structural remodelling in Atrial Fibrillation, we performed NanoString GeoMx Digital Spatial Profiling (DSP) of tissue biopsies from AF and SR patients. Regions were selected from adipose tissue and atrail appendage tissue close or far apart from tissue interphase.

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Project description:Background: Atrial fibrillation (AF) causes atrial remodeling, and the left atrium (LA) is the favored substrate for maintaining AF. However, it remains unclear if AF remodels both atria differently and contributes to LA arrhythmogenesis and thrombogenesis. Results: AF was associated with differential LA-to-RA gene expression related to specific ion channels and pathways as well as upregulation of thrombogenesis-related genes in the LA appendage. Targeting the molecular mechanisms underlying the LA-to-RA difference and AF-related remodeling in the LA appendage may help provide new therapeutic options in treating AF and preventing thromboembolism in AF. Paired left atrial and right atrial specimens were obtained from 13 patients with persistent AF receiving valvular surgery. The Paired specimens were sent for microarray comparison. Selected results were validated by quantitative real time-PCR (q-PCR) and Western blotting. Ultrastructural changes in the atria were evaluated by immunohistochemistry.

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