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Transcriptional changes following HIV infection of choroid plexus brain organoids

ABSTRACT: Transcriptional changes following HIV infection of choroid plexus brain organoids

PROVIDER: PRJNA1091542 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR28435109_1.fastq.gz	Fastqsanger.gz
	SRR28435109_2.fastq.gz	Fastqsanger.gz
	SRR28435110_1.fastq.gz	Fastqsanger.gz
	SRR28435110_2.fastq.gz	Fastqsanger.gz
	SRR28435111.fastq.gz	Fastqsanger.gz

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Transcriptional changes following HIV infection of choroid plexus brain organoids

Project description:We employed iPSC-derived choroid plexus brain organoids to explore the impact of HIV infection on microglia, elucidating alterations in the host gene profile within the central nervous system. We conducted single-cell RNA sequencing to elucidate the changes in microglia upon HIV infection, leading to neural cell damage

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Project description:Choroid plexus secretes cerebrospinal fluid important for brain development and homeostasis. The OTX2 homeoprotein is critical for choroid plexus development and remains highly expressed in adult choroid plexus. Through RNA sequencing analyses of constitutive and conditional knockdown adult mouse models, we reveal putative roles for OTX2 in choroid plexus function, including cell signaling and adhesion, and show that it regulates the expression of factors secreted into cerebrospinal fluid, notably transthyretin. We also show that Otx2 expression impacts choroid plexus immune and stress responses, and also affects splicing which leads to changes in mRNA isoforms of proteins implicated in oxidative stress response and DNA repair. Through mass spectrometry analysis of OTX2 protein partners in the choroid plexus, and in known non-cell autonomous target regions such as visual cortex and subventricular zone, we identified putative targets involved in cell adhesion, chromatin structure and RNA processing. Thus, OTX2 retains important roles in choroid plexus function and brain homeostasis throughout life.

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