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Gene expression changes in conditional METTL3 overexpression mouse uterus compared to control mouse uterus on gestational day 8

ABSTRACT: Gene expression changes in conditional METTL3 overexpression mouse uterus compared to control mouse uterus on gestational day 8

PROVIDER: PRJNA1096723 | ENA |

REPOSITORIES: ENA

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Gene expression changes in conditional METTL3 overexpression mouse uterus compared to control mouse uterus on gestational day 8

Project description:We specifically over-expressed Mettl3 in mouse uterus using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in mouse uterus during decidualization, uterine tissues were collected from METTL3-OE and control mice on gestational day 8 and subjected to RNA-seq analysis.

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Project description:We specifically deleted Mettl3 in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in uterus, uterine tissues were collected from Mettl3f/f and Mettl3d/d mice on gestational day 4 and subjected to RNA-seq analysis.

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Gene expression changes in Mettl3ed/ed mouse uterus compared to Mettl3f/f mouse uterus on gestational day 4

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Gene expression changes in Mettl3-deleted mouse uterus on gestational day 4

Project description:Gene expression changes in Mettl3-deleted mouse uterus on gestational day 4

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Global m6A-modified mRNAs in mouse uterus on gestational day 4 [meRIP-seq]

Project description:Global m6A-modified mRNAs in wild-type mouse uterus on gestational day 4 were analyzed by using methylated RNA immunoprecipitation sequencing (MeRIP-seq)

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Gene expression changes in Mettl3-deleted mouse oviduct on gestational day 3

Project description:We specifically deleted Mettl3 in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Mettl3 function in oviduct, whole oviduct were collected from Mettl3f/f and Mettl3d/d mice on gestational day 3 and subjected to RNA-seq analysis.

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Gene expression changes in Mettl3ed/ed mouse uterus compared to Mettl3f/f mouse uterus on gestational day 4

Project description:Gene expression changes in Mettl3ed/ed mouse uterus compared to Mettl3f/f mouse uterus on gestational day 4

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METTL3-dependent m6A methylation facilitates uterine receptivity and female fertility via balancing estrogen and progesterone signaling

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