Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell RNA sequencing of immune cells from murine GBM tumors

ABSTRACT: Single-cell RNA sequencing of immune cells from murine GBM tumors

PROVIDER: PRJNA1101540 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Single-cell RNA sequencing of immune cells from murine GBM tumors

Project description:We analyzed effects of IFNAR deficiency on immune cells of the GBM TME and also analyzed how anti-PD1 affected these immune cells in absence of type I IFN signaling. We also analyzed the effects of anti-PD1 treatment on the immune cell populations in absence of IFN production.

2024-10-07 | GSE264251 | GEO

scRNA of GBM tumors

Project description:scRNA of GBM tumors

| PRJNA996138 | ENA

GBM brain tumors

Project description:This SuperSeries is composed of the following subset Series: GSE24446: Genetic abnormalities in GBM brain tumors GSE24452: Genetic abnormalities in various cell subpopulations of GBM brain tumors GSE24557: Exon-level expression profiles of GBM brain tumors Refer to individual Series

2010-11-21 | E-GEOD-24558 | biostudies-arrayexpress

scRNA of GBM tumors

Project description:Glioblastoma (GBM) presents a formidable clinical challenge due to its complex microenvironment. Here, we introduce tumor-associated foam cells (TAFs), a previously unidentified immune cell entity of lipid droplet (LD)-loaded macrophages, in GBM. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we reveal that TAFs exhibit distinct pro-tumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, and impaired phagocytosis. Moreover, TAF presence correlates with worse patient outcome. Our mechanistic investigations demonstrate that TAF formation is facilitated by lipid cargo transfer from extracellular vesicles released by GBM cells. Importantly, we demonstrate that targeting key enzymes involved in LD formation, such as DGAT1 or ACSL, effectively disrupts TAF functionality. This study establishes TAFs as a prominent immune cell entity in GBM and provides valuable insights into their interplay within the microenvironment. Disrupting LD formation to target TAFs presents an interesting avenue for future therapeutic development in GBM.

2023-08-16 | GSE237673 | GEO

Single-cell RNA sequencing analysis of mouse normal brain and GBM tumors

Project description:Single-cell RNA sequencing analysis of mouse normal brain and GBM tumors

| PRJNA819475 | ENA

Single RNA-Seq on GBM cells from human GBM sample

Project description:Single RNA-Seq on GBM cells from human GBM sample

| PRJNA820777 | ENA

Transcription profiling of human glioblastoma multiforme tumors taken before dendritic cell vaccination, recurrent tumors after vaccination and control GBM tumors

Project description:Human Glioblastoma Multiforme tumors taken before dendritic cell vaccination, the recurrent tumors taken after vaccination and control GBM tumors from non vaccinated patients. Experiment Overall Design: Six Glioblastoma Multiforme patients underwent surgery. Their brain tumors were removed and analyzed via microarray. The lysate from the tumors were cultured with the patients' dendritic cells and the DCs were injected back into the patients. The patients GBMs returned and they underwent surgery a second time and those tumors were also analyzed via microarray. Tumors from the first and second GBM surgeries of 5 patients who did not receive DC vaccines are included as controls.

2009-04-11 | E-GEOD-11100 | biostudies-arrayexpress

Radiation dose-fractionation effects on immune modulation in murine mammary tumors

Project description:Radiation dose-fractionation effects on immune modulation in murine mammary tumors

| PRJNA681823 | ENA

Extra-tumoral analysis of GBM bearing murine brains

Project description:Extra-tumoral analysis of GBM bearing murine brains

| PRJNA884844 | ENA

Genetic abnormalities in various cell subpopulations of GBM brain tumors

Project description:GBM is a heterogenous tumor. Based on membrane protein expression, the GBM single cell dissociates were seperated into different subfractions by FACS assay. The genomic aberration among each populations were compared by analysis of CGH data. Genomic DNA were extracted from sorted cell population and CGH assay were performed to compare the similarity genomic abnormality among different cell groups.

2010-11-21 | E-GEOD-24452 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data