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ABSTRACT: Gene expression profile analysis of the subregions of the adult female reproductive tract in the brown anole, Anolis sagrei

PROVIDER: PRJNA1111490 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29021670_1.fastq.gz	Fastqsanger.gz
	SRR29021670_2.fastq.gz	Fastqsanger.gz
	SRR29021671_1.fastq.gz	Fastqsanger.gz
	SRR29021671_2.fastq.gz	Fastqsanger.gz
	SRR29021672_1.fastq.gz	Fastqsanger.gz

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Project description:This project aims to establish the embryonic anole lung as a model for investigating lung development and more general epithelial morphogenesis by generating a set of single-cell RNA-seq (scRNA-seq) data from late-stage embryonic lungs taken from brown anoles (Anolis sagrei). The anole lung, with its simple architecture, provides a novel tool for investigating signaling in a less complex respiratory system than the murine lung, and this data set would be a large advance in making this system more widely known and accesible among developmental biologists.

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Project description:The brown anole lizard, Anolis sagrei, is an emerging squamate model for developmental and functional genetic studies. To develop additional tools and resources for mechanistic studies of signaling pathways and cellular processes in A. sagrei, we established an in vitro system. Using this approach, we studied Hedgehog (Hh) signaling, one of the key developmental signaling pathways, which has evolved across the metazoa. We investigated Hh pathway-induced transcriptional changes in two evolutionarily distinct tetrapods: A. sagrei, and M. musculus, to identify the species-specific and evolutionarily shared responses. We report that ~45 % of genes induced as a response to Hh pathway activation in A. sagrei, are shared with M. musculus. To further increase the versatility of A. sagrei as a squamate model system for gene editing and genomic studies, we established and characterized a new immortalized A. sagrei embryonic fibroblast cell line ASEC-1. We performed whole-genome sequencing analysis to annotate the set of polymorphisms within this cell line. We conclude that transcriptome characterization of the ASEC-1 cell line would permit further investigations dissecting the complex biological and evolutionary aspects of Hh signaling.

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Project description:Anolis sagrei (brown anole lizard) genome, rAnoSag1, sequence data

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Project description:Anolis sagrei (brown anole lizard) genome, rAnoSag2, sequence data

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