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Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [RNA-seq]

ABSTRACT: Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [RNA-seq]

PROVIDER: PRJNA1113522 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29081702_1.fastq.gz	Fastqsanger.gz
	SRR29081702_2.fastq.gz	Fastqsanger.gz
	SRR29081703_1.fastq.gz	Fastqsanger.gz
	SRR29081703_2.fastq.gz	Fastqsanger.gz
	SRR29081704_1.fastq.gz	Fastqsanger.gz

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Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation

Project description:Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation

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Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [CUT&Tag]

Project description:Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [CUT&Tag]

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Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [ATAC-seq]

Project description:Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [ATAC-seq]

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Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [scRNA-Seq]

Project description:Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [scRNA-Seq]

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Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [CUT&Tag]

Project description:Granulosa cells (GCs) are the most dynamically responsive cell lineage to encourage continuous folliculogenesis; however, developmental dynamics and interplay with downstream transcription circuitry remain unclear. Here, we unravel the redistribution of genome-wide chromatin areas that drive broad developmental-related transcriptomic alterations during follicular maturation in murine and porcine GCs. Distinct GC-activated accessibility regions (GAAs) at the ovulatory phase are responsible for augmenting flanking GC-involved developmental gene (GDG) expression, which are essential for transcriptional responses to developmental cues. Mechanistically, the transcription factor (TF) Fosl2 is strongly recruited to GAAs, facilitating chromatin accessibility state transition. Elevated GAA signals driven by Fosl2 loading induce a significant upregulation of adjacent GDG expression. Additionally, GC-specific Fosl2 deletion in mice perturbs GC cellularity, leading to subfertility related to reproductive aging. Together, we highlight a dynamic chromatin accessibility landscape during follicular maturation, revealing the indispensable Fosl2 function not only controls transcriptional activation via a reconfigured chromatin state, but also orchestrates intricate signaling pathways that are fundamental for ovulation and reproduction.

2024-06-01 | GSE267851 | GEO

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [ATAC-seq]

2024-06-01 | GSE267850 | GEO

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [RNA-seq]

2024-06-01 | GSE267849 | GEO

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [scRNA-Seq]

2024-11-10 | GSE281100 | GEO

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-01 | GSE267974 | GEO

Transcription profiling of mouse primary splenocytes enriched or depleted of follicular dendritic cells to study the events leading to maturation of follicular dendritic cells and lymphoid germinal centers.

Project description:Comparison of follicular dendritic cell-enriched versus -depleted splenocytes. Affinity maturation and Ab class switches occur in lymphoid germinal centers (GCs), in which differentiation and maintenance depend on lymphotoxin (LT) signaling and include differentiation of follicular dendritic cells (FDCs). The events leading to FDC and GC maturation are poorly defined. Using several approaches of functional genomics, we enumerated transcripts affected in mice by suppressing LT receptor (LTR) signaling and/or overrepresented in FDC-enriched GC isolates. Protein expression analysis of 3 of 12 genes both enriched in FDCs and down-regulated by LTR signaling suppression validated them as FDC markers. Functional analysis of one of these three, clusterin, suggests a role as an FDC-derived trophic factor for GC B cells. Hence, the set of genes presented in this study includes markers emanating from LTR signaling and transcripts relevant to GC and FDC function.

2007-09-21 | E-GEOD-2123 | biostudies-arrayexpress

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