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Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Sus scrofa

PROVIDER: GSE267974 | GEO | 2024/06/01

REPOSITORIES: GEO

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Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [CUT&Tag]

Project description:Granulosa cells (GCs) are the most dynamically responsive cell lineage to encourage continuous folliculogenesis; however, developmental dynamics and interplay with downstream transcription circuitry remain unclear. Here, we unravel the redistribution of genome-wide chromatin areas that drive broad developmental-related transcriptomic alterations during follicular maturation in murine and porcine GCs. Distinct GC-activated accessibility regions (GAAs) at the ovulatory phase are responsible for augmenting flanking GC-involved developmental gene (GDG) expression, which are essential for transcriptional responses to developmental cues. Mechanistically, the transcription factor (TF) Fosl2 is strongly recruited to GAAs, facilitating chromatin accessibility state transition. Elevated GAA signals driven by Fosl2 loading induce a significant upregulation of adjacent GDG expression. Additionally, GC-specific Fosl2 deletion in mice perturbs GC cellularity, leading to subfertility related to reproductive aging. Together, we highlight a dynamic chromatin accessibility landscape during follicular maturation, revealing the indispensable Fosl2 function not only controls transcriptional activation via a reconfigured chromatin state, but also orchestrates intricate signaling pathways that are fundamental for ovulation and reproduction.

2024-06-01 | GSE267851 | GEO

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [ATAC-seq]

2024-06-01 | GSE267850 | GEO

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [RNA-seq]

2024-06-01 | GSE267849 | GEO

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [scRNA-Seq]

2024-11-10 | GSE281100 | GEO

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation

Project description:Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation

| PRJNA1113965 | ENA

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [CUT&Tag]

Project description:Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [CUT&Tag]

| PRJNA1113520 | ENA

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [ATAC-seq]

Project description:Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [ATAC-seq]

| PRJNA1113521 | ENA

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [RNA-seq]

Project description:Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [RNA-seq]

| PRJNA1113522 | ENA

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [scRNA-Seq]

Project description:Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation [scRNA-Seq]

| PRJNA1182281 | ENA

H4K44 Acetylation Facilitates Chromatin Accessibility during Meiosis.

Project description:Meiotic recombination hotspots are associated with histone post-translational modifications and open chromatin. However, it remains unclear how histone modifications and chromatin structure regulate meiotic recombination. Here, we identify acetylation of histone H4 at Lys44 (H4K44ac) occurring on the nucleosomal lateral surface. We show that H4K44 is acetylated at pre-meiosis and meiosis and displays genome-wide enrichment at recombination hotspots in meiosis. Acetylation at H4K44 is required for normal meiotic recombination, normal levels of double-strand breaks (DSBs) during meiosis, and optimal sporulation. Non-modifiable H4K44R results in increased nucleosomal occupancy around DSB hotspots. Our results indicate that H4K44ac functions to facilitate chromatin accessibility favorable for normal DSB formation and meiotic recombination.

| S-EPMC4793274 | biostudies-literature

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