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A niche-derived non-ribosomal peptide triggers planarian sexual development.

ABSTRACT: A niche-derived non-ribosomal peptide triggers planarian sexual development.

PROVIDER: PRJNA1113555 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29082524_1.fastq.gz	Fastqsanger.gz
	SRR29082524_2.fastq.gz	Fastqsanger.gz
	SRR29082525_1.fastq.gz	Fastqsanger.gz
	SRR29082525_2.fastq.gz	Fastqsanger.gz
	SRR29082526_1.fastq.gz	Fastqsanger.gz

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A niche-derived non-ribosomal peptide triggers planarian sexual development.

Project description:Germ cells are regulated by local microenvironments (niches), which secrete instructive cues. Conserved developmental signaling molecules act as niche-derived regulatory factors, yet other types of niche signals remain to be identified. Single-cell RNA-sequencing of sexual planarians revealed niche cells expressing a non-ribosomal peptide synthetase (nrps). Inhibiting nrps led to loss of female reproductive organs and testis hyperplasia. Mass spectrometry detected the dipeptide β-alanyl-tryptamine (BATT), which is associated with reproductive system development and requires nrps and a monoamine-transmitter-synthetic enzyme (AADC) for its production. Exogenous BATT rescued the reproductive defects after nrps or aadc inhibition, restoring fertility. Thus, a non-ribosomal, monoamine-derived peptide provided by niche cells acts as a critical signal to trigger planarian reproductive development. These findings reveal an unexpected function for monoamines in niche-germ cell signaling. Furthermore, given the recently reported role for BATT as a male-derived factor required for reproductive maturation of female schistosomes, these results have important implications for the evolution of parasitic flatworms and suggest a potential role for non-ribosomal peptides as signaling molecules in other organisms.

2024-06-06 | GSE267865 | GEO

A niche-derived non-ribosomal peptide triggers planarian sexual development.

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2021-12-23 | GSE191062 | GEO

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