Macaca mulatta
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA111495 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Differentially expressed genes among motor and prefrontal areas of macaque monkey neocortex
| PRJNA101831 | ENA
Project description:Functional annotation of genes differentially expressed between primary motor and prefrontal association cortices of macaque brain
| PRJNA167032 | ENA
Project description:Differentially expressed genes in pneumococcus-infected THP-1 monocytes
| PRJNA676108 | ENA
Project description:Chronic binge alcohol administration accentuates expression of pro-fibrotic and inflammatory genes in the skeletal muscle of simian immunodeficiency virus-infected macaques
| PRJNA254453 | ENA
Project description:Chronic Binge Alcohol Administration Dysregulates Expression of Hippocampal Genes Involved in Immune Function, Neurotransmission and Neurogenesis in Simian Immunodeficiency Virus-Infected Macaques
| PRJNA286203 | ENA
Project description:Simian Immunodeficiency Virus (SIV) infected rhesus macaques
| PRJNA765696 | ENA
Project description:Aged animals generate a robust immune response against swine origin 2009 pandemic H1N1 influenza A virus
| PRJNA168088 | ENA
Project description:The study describes miRNA expression in colonic epithelium of chronic SIV-infected rhesus macaques. We profiled and characterized miRNA/mRNA expression exclusively in colonic epithelium (CE) of 12 chronically SIV-infected and 8 control rhesus macaques (RMs). About 46 miRNAs were differentially expressed (DE) (20-up and 26-down) in CE during chronic SIV infection. Using TargetScan, we bioinformatically crossed the predicted targets of DE miRNAs to genome-wide transcriptomic data and identified several critical miRNA-mRNA pairings that suggested miRNA-mediated regulation of aberrant epithelial gene expression in CE. Immunofluorescence, luciferase reporter and miRNA overexpression studies confirmed the ability of miR-130a and miR-212 to bind the 3’ UTR and downregulate protein expression of occludin (OCLN) and peroxisome proliferator activator receptor gamma (PPAR), respectively, two proteins with pivotal roles in epithelial barrier function. MiR-130a and miR-212 overexpression in Caco-2 cells significantly reduced transepithelial electrical resistance (TEER). Interestingly, delta-9-tetrahydrocannabinol (9-THC) treatment restored TEER to levels observed with control miRNA mimic. Finally, ex-vivo 9-THC treatment of colon tissue from chronically SIV-infected RMs significantly increased PPAR gene expression. Our findings suggest that dysregulated miR-130a and miR-212 expression in CE during chronic HIV/SIV infection can facilitate epithelial barrier disruption by downregulating OCLN and PPAR protein expression. Most importantly, our results highlight the beneficial effects of cannabinoids on epithelial barrier function in not just HIV/SIV but potentially other chronic intestinal inflammatory diseases.
2018-02-01 | GSE104767 | GEO
Project description:RNA sequencing of SIV infected rhesus macaque astroytes
| PRJNA297722 | ENA
Project description:Disease severity is associated with differential gene expression at the early and late phases of infection in non-human primates infected with different H5N1 highly pathogenic avian influenza viruses
| PRJNA248617 | ENA