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Transcription factors Sox8 and Sox10 contribute differentially to maintenance of the differentiated state in oligodendrocytes

ABSTRACT: Transcription factors Sox8 and Sox10 contribute differentially to maintenance of the differentiated state in oligodendrocytes

PROVIDER: PRJNA1120355 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29290900_1.fastq.gz	Fastqsanger.gz
	SRR29290900_2.fastq.gz	Fastqsanger.gz
	SRR29290901_1.fastq.gz	Fastqsanger.gz
	SRR29290901_2.fastq.gz	Fastqsanger.gz
	SRR29290886_1.fastq.gz	Fastqsanger.gz

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Transcription factors Sox8 and Sox10 contribute differentially to maintenance of the differentiated state in oligodendrocytes

Project description:To identify target genes of the transcription factors Sox8 and Sox10 in oligodendrocytes in a genome-wide and unbiased approach, we induced oligodendocyte-specific deletion of Sox8, Sox10 or a combination thereof (Sox8 knockout, Sox10 knockout, double knockout) in 2 months-old mice, dissected the corpus callosum of control and mutant mice after 21 days and isolated total RNA for ensuing RNA-Seq studies. Among others we detected substantial changes in the expression of genes associated with differentiation of oligodendrocytes and myelination in Sox10 knockout mice as well as double knockout mice but not in Sox8 knockout mice.

2024-08-28 | GSE269122 | GEO

SOX10 Single Transcription Factor Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

Project description:We report the use of a single transcription factor, SOX10, for the generation of oligodendrocytes from human pluripotent stem cells. We further used RNA sequencing to compare the oligodendrocytes derived from pluripotent stem cells to different primary cells. It was revealed that oligodendrocytes derived from pluripotent stem cells are representative of intermediate oligodendrocytes during embryonic development.

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Sox10 Binding Analysis in the Central and Peripheral Nervous System

Project description:ChIP-seq of Sox10 in spinal cord and sciatic nerve was performed to determine shared and unique binding sites for Sox10 in oligodendrocytes and Schwann cells, respectively. Sox10 is required for both Schwann cell and oligodendrocyte development. In addition, differentiation of myelinating glia is dependent upon axonal signaling, so these studies were performed in vivo.

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ATAC-seq of in vitro reprogrammed mouse pericytes to oligodendrocytes

Project description:Direct conversion of pericytes (PCs) into induced oligodendrocytes (iOPCs) by ectopic expression of Olig2 and Sox10 (2F) was assessed by chromatin accessibility profiling (by ATAC-seq). Samples were collected before and after direct conversion (at 3 different time points/passages - p5, p15 and p25).

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RNA-seq of in vitro reprogrammed mouse pericytes to oligodendrocytes

Project description:Direct conversion of pericytes (PCs) or mouse embryonic fibroblasts (MEFs) into induced oligodendrocytes (iOPCs) by ectopic expression of Olig2, Sox10 and Nkx6.2 was assessed by transcriptome profiling (RNA-seq). Samples were collected before and after direct conversion (for PCs at 3 different time points/passages - p5, p15 and p25)

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Transcription profiling of mice mutant for Sox8 and Sox9 has early testicular sterility

Project description:To study a possible redundant role of mouse Sox8 and Sox9 after testis induction we generated double mutants by AMH-Cre conditional inactivation of Sox9 in a Sox8-/- background. Double mutants arrest spermatogenesis in early pubescence. We performed expression profiling to explore causes. AMH-Cre/+;Sox9flox/flox;Sox8-/- is a conditional homozygous knockout of SOX9 in a sox8-/- background, using an AMH-CRE line where the CRE recombinase is expressed under the promoter region of the human AMH gene in Sertoli cells starting at E13.5. The specific cross was between males of the genotype +/+;Sox9flox/flox;Sox8-/- and females of the genotype AMH-Cre/+;Sox9flox/flox;Sox8+/-.

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Pre-existent adult sox10+ cardiomyocytes contribute to myocardial regeneration in the zebrafish

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