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Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration [scRNA-seq]

ABSTRACT: Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration [scRNA-seq]

PROVIDER: PRJNA1122783 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29364678_1.fastq.gz	Fastqsanger.gz
	SRR29364678_2.fastq.gz	Fastqsanger.gz
	SRR29364679_1.fastq.gz	Fastqsanger.gz
	SRR29364679_2.fastq.gz	Fastqsanger.gz
	SRR29364680_1.fastq.gz	Fastqsanger.gz

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Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration [bulk RNA-seq]

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Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration [scRNA-seq]

Project description:The plasticity of plant cells underlies their wide capacity to regenerate, with increasing evidence in plants and animals implicating cell cycle dynamics in cellular reprogramming. To investigate the cell cycle during cellular reprogramming, we developed a comprehensive set of cell cycle phase markers in the Arabidopsis root. Using single-cell RNA-seq profiles and live imaging during regeneration, we found that a subset of cells near an ablation injury dramatically increases division rate by truncating G1 phase. Cells in G1 undergo a transient nuclear peak of glutathione (GSH) prior to coordinated entry into S phase followed by rapid divisions and cellular reprogramming. A symplastic block of the ground tissue impairs regeneration, which is rescued by exogenous GSH. We propose a model in which GSH from the outer tissues is released upon injury licensing an exit from G1 near the wound to induce rapid cell division and reprogramming.

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Mouse sciatic nerve LC-MSMS - Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration

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Untargeted metabolomics links glutathione to bacterial cell cycle progression

Project description:Cell cycle progression requires the coordination of cell growth, chromosome replication, and division. Consequently, a functional cell cycle must be coupled with metabolism. However, direct measurements of metabolome dynamics remained scarce, in particular in bacteria. Here, we describe an untargeted metabolomics approach with synchronized Caulobacter crescentus cells to monitor the relative abundance changes of ~400 putative metabolites as a function of the cell cycle. While the majority of metabolite pools remains homeostatic, ~14% respond to cell cycle progression. In particular, sulfur metabolism is redirected during the G1-S transition, and glutathione levels periodically change over the cell cycle with a peak in late S phase. A lack of glutathione perturbs cell size by uncoupling cell growth and division through dysregulation of KefB, a K+/H+ antiporter. Overall, we here describe the impact of the C. crescentus cell cycle progression on metabolism, and in turn relate glutathione and potassium homeostasis to timely cell division.

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