Single cell gene expression profile for normal adult canine neuroretina
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1134167 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Our understanding of disease is increasingly informed by changes in gene expression between normal and abnormal tissues. The release of the canine genome sequence in 2005 provided an opportunity to understand health and disease in the dog using investigative techniques including gene expression profiling. Accordingly, we now present a publicly accessible canine normal tissue gene expression database that will streamline the study of canine tissues and facilitate comparative genomic analysis with other mammals. The Affymetrix platform was utilized to catalogue the genetic signatures of normal canine tissues including: liver, kidney, heart, lung, cerebrum, lymph node, spleen, jejunum, pancreas and skeletal muscle. The quality of the database was assessed in several ways. Organ defining gene sets were identified for each tissue and functional enrichment analysis revealed themes consistent with known physio-anatomic functions for each organ. In addition, a comparison of orthologous gene expression between matched canine and human normal tissues uncovered remarkable similarity. Public access and use of this data, using infrastructure identical to that currently in use for human normal tissues, has been established and allows for additional cross-species comparisons. To demonstrate the utility of this dataset, novel canine gene annotations were established based on comparative analysis of dog and human tissue selective gene expression and manual curation of canine probeset mapping. It is expected that this dataset will contribute to more advanced study of disease in the dog and biologically robust biomedical studies that utilize the dog as a model for translational research.
2010-12-31 | GSE20113 | GEO
Project description:Retinal single cell gene expression profile from two male dogs at 40 weeks of age.
2024-10-01 | GSE271945 | GEO
Project description:Canine osteosarcoma tissues vs. normal bone
| PRJNA437637 | ENA
Project description:Our understanding of disease is increasingly informed by changes in gene expression between normal and abnormal tissues. The release of the canine genome sequence in 2005 provided an opportunity to understand health and disease in the dog using investigative techniques including gene expression profiling. Accordingly, we now present a publicly accessible canine normal tissue gene expression database that will streamline the study of canine tissues and facilitate comparative genomic analysis with other mammals. The Affymetrix platform was utilized to catalogue the genetic signatures of normal canine tissues including: liver, kidney, heart, lung, cerebrum, lymph node, spleen, jejunum, pancreas and skeletal muscle. The quality of the database was assessed in several ways. Organ defining gene sets were identified for each tissue and functional enrichment analysis revealed themes consistent with known physio-anatomic functions for each organ. In addition, a comparison of orthologous gene expression between matched canine and human normal tissues uncovered remarkable similarity. Public access and use of this data, using infrastructure identical to that currently in use for human normal tissues, has been established and allows for additional cross-species comparisons. To demonstrate the utility of this dataset, novel canine gene annotations were established based on comparative analysis of dog and human tissue selective gene expression and manual curation of canine probeset mapping. It is expected that this dataset will contribute to more advanced study of disease in the dog and biologically robust biomedical studies that utilize the dog as a model for translational research. 39 pathologically normal organ samples were collected from four dogs, 10 organs from each dog. Organ samples included the pancreas, kidney, liver, lung, heart, skeletal muscle, jejunum, cerebrum, spleen and peripheral lymph node.
2010-12-31 | E-GEOD-20113 | biostudies-arrayexpress
Project description:Transcriptomic profile of canine mammary ductal carcinoma
| PRJNA841500 | ENA
Project description:To identify miRNAs associated with retinal development and degeneration in dogs affected with xlpra2, an early-onset canine retinal degeneration caused by a microdeletion in RPGRORF15. XLPRA2-mutant and normal retinas were selected at different ages for RNA extraction and hybridization on Affymetrix miRNA-specific microarrays.
2014-12-31 | GSE35205 | GEO
Project description:Comparison of the gene expression profile in lungs from dogs with spontaneous canine idiopathic pulmonary fibrosis and from control dogs with histologically normal lungs.
2013-10-01 | E-MEXP-3671 | biostudies-arrayexpress
Project description:Molecular mechanisms of the canine mammary malignancy. RNA isolated from canine mammary tumours of the 3rd grade of malignancy was pooled and hybrydized on the same microarray as RNA isolated from canine mammary tumours of the 1st grade of malignancy. Based on the results the "malignancy portrait" was assessed.
2013-10-01 | GSE44033 | GEO
Project description:Single nucleus inDrops to profile adult human kidney
| PRJNA464435 | ENA
Project description:Canine muscular dystrophy (CXMDJ) is a dog model of the lethal X-linked muscle disorder Duchenne muscular dystrophy (DMD), which is caused by loss of dystrophin. Gene expression profile was analyzed in the diaphragm muscles of normal Beagle dogs and CXMDJ before and 1 hour after initial respiration.
2012-10-31 | GSE32460 | GEO