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Plasmodium berghei ANKA

ABSTRACT: Feeding with a ketonic diet confers complete protection against malaria

PROVIDER: PRJNA1138275 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29907962_1.fastq.gz	Fastqsanger.gz
	SRR29907962_2.fastq.gz	Fastqsanger.gz
	SRR29907963_1.fastq.gz	Fastqsanger.gz
	SRR29907963_2.fastq.gz	Fastqsanger.gz
	SRR29907964_1.fastq.gz	Fastqsanger.gz

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Gene profiling of spleens of adult protected rats from Plasmodium berghei ANKA

Project description:The studies reported here were designed to define in more detail the effector cells responsible for the transfer of protective immunity to young host against P. berghei infection, and to investigate the genes expressed in spleen cells of adult protected rats capable of transferring protection to young rats. Keywords: age, malaria, protection, rat

2006-09-01 | GSE4552 | GEO

Feeding with a ketonic diet confers complete protection against malaria

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Project description:Most malaria drug development focuses on parasite stages detected in red-blood cells even though to achieve eradication next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be preferable. We applied a multifactorial approach to a set of >4,000 commercially available compounds with previously demonstrated blood stage activity (IC50 < 1 M-BM-5M), and identified chemical scaffolds with potent activity against both forms. From this screen, we identified an imidazolopiperazine scaffold series that was highly enriched among compounds active against Plasmodium liver stages. Our orally bioavailable lead imidazolopiperazine confers complete causal prophylactic protection (15 mg/kg) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity. The open source chemical tools resulting from our effort provide starting points for future drug discovery programs, as well as opportunities for researchers to investigate the biology of exo-erythrocytic forms. Genome DNA from IP resistant strains vs. Reference 3D7 or Dd2

2011-10-31 | E-GEOD-32485 | biostudies-arrayexpress

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Project description:Most malaria drug development focuses on parasite stages detected in red-blood cells even though to achieve eradication next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be preferable. We applied a multifactorial approach to a set of >4,000 commercially available compounds with previously demonstrated blood stage activity (IC50 < 1 µM), and identified chemical scaffolds with potent activity against both forms. From this screen, we identified an imidazolopiperazine scaffold series that was highly enriched among compounds active against Plasmodium liver stages. Our orally bioavailable lead imidazolopiperazine confers complete causal prophylactic protection (15 mg/kg) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity. The open source chemical tools resulting from our effort provide starting points for future drug discovery programs, as well as opportunities for researchers to investigate the biology of exo-erythrocytic forms.

2011-10-31 | GSE32485 | GEO

Alterations in the Brain Transcriptome in Plasmodium Berghei ANKA Infected Mice

Project description:We have used cDNA microarrays to compare gene expression profiles in brains from normal mice to those infected with the Anka strain of Plasmodium berghei, a model of cerebral malaria. For each of three brains in each group, we computed ratios of all quantifiable genes with a composite reference sample and then computed ratios of gene expression in infected brains with untreated controls. Of the almost 12,000 unigenes adequateluy quantified in all arrays, about 3% were significantly downregulated (p<0.05, >50% fold change) and about 7% were upregulated. Upon inspection of the lists of regulated genes, we identified a high number encoding proteins of importance to normal brain function or associated with neuropathology. These results emphasize the important impact of malarial infection on gene expression in brain and provide tentative target biomarkers that might provide novel therapeutic targets for neurological sequelae of disease.

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Project description:Comparative analysis of the rodent malaria genome Plasmodium berghei ANKA

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Project description:Transcriptome profile of wild type Plasmodium berghei and PbUbc13 kinase/PK9 knockout parasites

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Project description:Single cell analysis reveals transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development

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