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Bulk RNA-seq of castration-resistant tumors from Ptenpc-/- mice reconstituted with either F10fl/fl or F10fl/fl LysM-Cre+ mice

ABSTRACT: Bulk RNA-seq of castration-resistant tumors from Ptenpc-/- mice reconstituted with either F10fl/fl or F10fl/fl LysM-Cre+ mice

PROVIDER: PRJNA1139726 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29971439.fastq.gz	Fastqsanger.gz
	SRR29971440.fastq.gz	Fastqsanger.gz
	SRR29971441.fastq.gz	Fastqsanger.gz
	SRR29971442.fastq.gz	Fastqsanger.gz
	SRR29971443.fastq.gz	Fastqsanger.gz

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Bulk RNA-seq of castration-resistant tumors from Ptenpc-/- mice reconstituted with either F10fl/fl or F10fl/fl; LysM-Cre+ mice

Project description:PTEN is one of the most altered tumor suppressor genes in human prostate cancer (PCa). Prostate specific-Pten-deficient mouse models develop prostate cancer eventually progressing to castration-resistant prostate cancer (CRPC), also due to alterations of the tumor immune infiltrate. By using single-cell RNA-seq, we report the identification of a subset of CD84+; CD11b+; Ly6G+; Ly6Clow immunosuppressive neutrophils that secreted the coagulation factor X (FX) into the prostate TME to directly promote PCa growth.

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