Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Jiradej Makjaroen
LAB HEAD: Asada Leelahavanichkul
PROVIDER: PXD041265 | Pride | 2023-07-20
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
CM_Ezh2_KO_Set1_F.msf | Msf | |||
CM_Ezh2_KO_Set1_F1.mgf | Mgf | |||
CM_Ezh2_KO_Set1_F1.raw | Raw | |||
CM_Ezh2_KO_Set1_F2.mgf | Mgf | |||
CM_Ezh2_KO_Set1_F2.raw | Raw |
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International journal of molecular sciences 20230615 12
The O6-methylguanine-DNA methyltransferase (MGMT) is a DNA suicide repair enzyme that might be important during sepsis but has never been explored. Then, the proteomic analysis of lipopolysaccharide (LPS)-stimulated wild-type (WT) macrophages increased proteasome proteins and reduced oxidative phosphorylation proteins compared with control, possibly related to cell injury. With LPS stimulation, <i>mgmt</i> null (<i>mgmt</i><sup>flox/flox</sup>; LysM-Cre<sup>cre/-</sup>) macrophages demonstrated ...[more]