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USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis

ABSTRACT: USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis

PROVIDER: PRJNA1140356 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30001000_1.fastq.gz	Fastqsanger.gz
	SRR30001000_2.fastq.gz	Fastqsanger.gz
	SRR30001001_1.fastq.gz	Fastqsanger.gz
	SRR30001001_2.fastq.gz	Fastqsanger.gz
	SRR30001002_1.fastq.gz	Fastqsanger.gz

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USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis

Project description:In exploring the pathogenesis of periodontitis, we collected clinical gingival tissues from healthy donors and patients with severe periodontitis for RNA-Seq analysis, and calculated the significant statistical correlation values (R) between autophagy-related genes and inflammation-related genes in human gingival tissues, which could inform a potential therapeutic target for the treatment of periodontitis.

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